ID A0A287DFK8_ICTTR Unreviewed; 1336 AA.
AC A0A287DFK8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Synaptic Ras GTPase activating protein 1 {ECO:0000313|Ensembl:ENSSTOP00000032329.1};
GN Name=SYNGAP1 {ECO:0000313|Ensembl:ENSSTOP00000032329.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000032329.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000032329.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01011060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01011061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 43179.ENSSTOP00000032329; -.
DR Ensembl; ENSSTOT00000040540.1; ENSSTOP00000032329.1; ENSSTOG00000002482.3.
DR GeneTree; ENSGT00940000158438; -.
DR InParanoid; A0A287DFK8; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0043198; C:dendritic shaft; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:GOC.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR GO; GO:0016358; P:dendrite development; IEA:Ensembl.
DR GO; GO:0098880; P:maintenance of postsynaptic specialization structure; IEA:Ensembl.
DR GO; GO:0050771; P:negative regulation of axonogenesis; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0007389; P:pattern specification process; IEA:Ensembl.
DR GO; GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
DR GO; GO:0043113; P:receptor clustering; IEA:Ensembl.
DR GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
DR GO; GO:0043408; P:regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0050803; P:regulation of synapse structure or activity; IEA:Ensembl.
DR GO; GO:0008542; P:visual learning; IEA:Ensembl.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd13375; PH_SynGAP; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037779; SynGAP_PH.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR PANTHER; PTHR10194:SF25; RAS_RAP GTPASE-ACTIVATING PROTEIN SYNGAP; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 210..244
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 235..356
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 436..628
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 85..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 926..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1026..1146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1188..1254
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 85..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1061..1108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1125..1146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1270..1288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1307..1323
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1336 AA; 147579 MW; CE8E73DD23B3552C CRC64;
MHRTSLTVSV CLHPPDVRGP PMHRTQYVHS PYDRPGWNPR FCIISGNQLL MLDEDEIHPL
LIRDRRSESS RNKLLRRTVS VPVEGRPHGE HEYHLGRSRR KSVPGGKQYS MEAAPAAPFR
PSQGFLSRRL KSSIKRTKSQ PKLDRTSSFR QILPRFRSAD HDRARLMQSF KESHSHESLL
SPSSAAEALE LNLDEDSIIK PVHSSILGQE FCFEVTTSSG TKCFACRSAA ERDKWIENLQ
RAVKPNKDNS RRVDNVLKLW IIEARELPPK KRYYCELCLD DMLYARTTSK PRSASGDTVF
WGEHFEFNNL PAVRALRLHL YRDSDKKRKK DKAGYVGLVT VPVATLAGRH FTEQWYPVTL
PTGSGGSGGM GSGGGGGSGG GSGGKGKGGC PAVRLKARYQ TMSILPMELY KEFAEYVTNH
YRMLCAVLEP ALNVKGKEEV ASALVHILQS TGKAKDFLSD MAMSEVDRFM EREHLIFREN
TLATKAIEEY MRLIGQKYLK DAIGEFIRAL YESEENCEVD PIKCTASSLA EHQANLRMCC
ELALCKVVNS HCVFPRELKE VFASWRLRCA ERGREDIADR LISASLFLRF LCPAIMSPSL
FGLMQEYPDE QTSRTLTLIA KVIQNLANFS KFTSKEDFLG FMNEFLELEW GSMQQFLYEI
SNLDTLTNSS SFEGYIDLGR ELSTLHALLW EVLPQLSKEA LLKLGPLPRL LNDISTALRN
PNIQRQPSRQ SERPRPQPVV LRGPSAEMQG YMMRDLNSSI DLQSFMARGL NSSMDMARLP
SPTKEKPPPP PPGGGKDLFY VSRPPLARSS PAYCTSSSDI TEPEQKMLSV NKSVSMLDLQ
GDGPGGRLNS SSVSNLAAVG DLLHSSQASL TAALGLRPAP AGRLSQGSGS SITAAGMRLS
QMGVTTDGVP AQQLRIPLSF QNPLFHMAAD GPGPPAGHGG SGGHGPPSSH HHHHHHHHHR
GGEPPGDTFA PFHGYSKSED LSSGVPKPPA ASILHSHSYS DEFGPSGTDF TRRQLSLQDN
LQHMLSPPQI TIGPQRPAPS GPGGGSGGGS GGGGGGQPPP LQRGKSQQLT VSAAQKPRPS
SGNLLQSPEP SYGPARPRQQ SLSKEGSIGG SGGSGGGGGG GLKPSITKQH SQTPSTLNPT
MPASERTVAW VSNMPHLSAD IESAHIEREE YKLKEYSKSM DESRLDRVKE YEEEIHSLKE
RLHMSNRKLE EYERRLLSQE EQTSKILMQY QARLEQSEKR LRQQQVEKDS QIKSIIGRLM
LVEEELRRDH PAMAEPLPEP KKRLLDAQER QLPPLGPTNP RVTLAPPWNG LAPPAPPPPP
RLQITENGEF RNTADH
//
