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Database: UniProt
Entry: A0A287HA85_HORVV
LinkDB: A0A287HA85_HORVV
Original site: A0A287HA85_HORVV 
ID   A0A287HA85_HORVV        Unreviewed;      1595 AA.
AC   A0A287HA85;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   05-JUN-2019, entry version 10.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
OS   Hordeum vulgare subsp. vulgare (Domesticated barley).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Hordeinae; Hordeum.
OX   NCBI_TaxID=112509 {ECO:0000313|EnsemblPlants:HORVU2Hr1G020260.19, ECO:0000313|Proteomes:UP000011116};
RN   [1] {ECO:0000313|EnsemblPlants:HORVU2Hr1G020260.19, ECO:0000313|Proteomes:UP000011116}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Morex {ECO:0000313|EnsemblPlants:HORVU2Hr1G020260.19}, and
RC   subsp. vulgare {ECO:0000313|Proteomes:UP000011116};
RX   PubMed=23075845; DOI=10.1038/nature11543;
RG   The International Barley Genome Sequencing Consortium;
RT   "A physical, genetic and functional sequence assembly of the barley
RT   genome.";
RL   Nature 491:711-716(2012).
RN   [2] {ECO:0000313|EnsemblPlants:HORVU2Hr1G020260.19}
RP   IDENTIFICATION.
RC   STRAIN=subsp. vulgare {ECO:0000313|EnsemblPlants:HORVU2Hr1G020260.19};
RG   EnsemblPlants;
RL   Submitted (OCT-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EnsemblPlants; HORVU2Hr1G020260.19; HORVU2Hr1G020260.19; HORVU2Hr1G020260.
DR   EnsemblPlants; HORVU2Hr1G020260.61; HORVU2Hr1G020260.61; HORVU2Hr1G020260.
DR   Gramene; HORVU2Hr1G020260.19; HORVU2Hr1G020260.19; HORVU2Hr1G020260.
DR   Gramene; HORVU2Hr1G020260.61; HORVU2Hr1G020260.61; HORVU2Hr1G020260.
DR   Proteomes; UP000011116; Unassembled WGS sequence.
DR   ExpressionAtlas; A0A287HA85; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR030559; PolZ_Rev3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   PANTHER; PTHR45812; PTHR45812; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011116};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011116};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      708    917       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      984   1431       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1494   1567       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION       12     38       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A287HA85}.
FT   REGION      310    444       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A287HA85}.
FT   REGION      836    869       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A287HA85}.
FT   COMPBIAS     22     38       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A287HA85}.
FT   COMPBIAS    310    337       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A287HA85}.
FT   COMPBIAS    338    352       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A287HA85}.
FT   COMPBIAS    355    374       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A287HA85}.
FT   COMPBIAS    415    437       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A287HA85}.
FT   COMPBIAS    848    862       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A287HA85}.
SQ   SEQUENCE   1595 AA;  176149 MW;  3E63BB1E215AF131 CRC64;
     MGHVHVTDFK FRPPLPGDFH PKTPQRKVDS SDESEHKTHS YNAAVKNPII WTSSTAPHAL
     ILGDSSTTHF MEGSSSNFRK RHTFMMLEAD SRVEGIINEK YKMYTSLSQT TADTKMVQSL
     LAIWEELEHL RLLDETKPAD IGRPPRDAVL KSFLHGIKYE SALSALDPKE EGSHHKDSSV
     EASEKLERCF KSLTDVIGTI TFSQNDCCEN IGSDNSAQRT SQTFDEHEKH VDSEALGLLS
     WMASSQAGEE PTTDDELVNE VILSPLFSKK SIEFALESAH LDFDSASQQE CQDILDTLEH
     VTGAEELNAQ KSYHSSPMLD GSTSVTNTIP QIDGSSDEKQ KGPQEYDQGK VTRRKIGTPS
     YSSSKNNSKL ASKQGGTELL WGSLPLSTKK RSHGNADGPV KISSGSAMPT EDPSSYKSKT
     EKNSRDMTDD TDKESSSSIG DDGSACLSVR DLMRRRRKGS FQPEKLDFGC SGAAACNMDK
     TSGIVISGGL EVHDVTSGLP NSEMSYSGGE YVRMTFAQKP PTGLEVSSAS IEHPEPAKLG
     SVDPLPFFNQ TAEENKENGS FQYMGSSELT PDTLGIPTHF QNDGSVLYLL THAFSPPSAA
     AVGQWLPQHT SSNSVSDDQE IEHHPTSRPH AEALAFMANS PVPGSASEHT TAAFIDTVMM
     KSDQSNKENE KLDDWHDFSQ ISAEDEKHKL TPLSQIGFRD PASTGGGQQL TILSIEVFAE
     SRADLRPDPR FDAINVVSLA VEDDGDNTVE VRVLIRGNND KLHGRRNLDG VIGCSVDVFP
     EEKDLLNHLI GALCSIDPDI LVGWEIQLGS LGFLAERAAY LGIGLLKRIS RTLPHESKHP
     PKNLAHESSQ APPKNLAHES SQAPEASPAD DVIVDVSEND WSHTHASGVH VGGRIVLNLW
     RLMRGEVKLN NYSLEAVADE VLRRKVPLVP TKTLNRWFAT GPGRGRHRCI EYVSSRAMLN
     LEIINQLDLV NRTSELARVF GIDFFSVLSR GSQFRVESML LRLAHTQNYL AISPGNQQVA
     SQPAMECMPL VMEPESAFYS DPVLVLDFQS LYPSMIIAYN LCYSTCLGKV FPSKSSVLGV
     SSYSADPHTI TDLKNQLLLT PNGVLYVQPE VRKGVVPRLL EEILSTRIMV KQAMKKLAPS
     QKVLQKILNA RQLALKLIAN VTYGYTAAGF SGRMPCAELA DSIVQCGRRT LETAISFVNQ
     HPLWNARVVY GDTDSMFVLL KGRSREEAFR IGKEIASLVT AINPDPVTLK FEKVYHPCFL
     LTKKRYVGYS YENPEQNEPI FDPKGIETVR RDTCPAVAKM LERSLRIMFE EQDLVKVKSY
     VERQWTRILS GKISIQDFVF AKEVRLGTYS ARASSLPPAA IVATKAMLSD PRAEPRYAER
     VPYVVIHGEP GARLVDMVID PYGLLQVGSP YRLNELYYIT KQIIPALQRV FGLLGVNLNK
     WFNEMPRPTR STLAKRQSAF GHGSRDSSSI RLGWNKKPSA KVARIDTYYM SSHCTICGDT
     VQGSETFCSY CLKNEAVVAT VVAGRTSKLE REIQHLAAIC GHCGGADWIV ESGVKCVSLA
     CPVFYERRKI QKELRVVSES AGEAGYYPFC CVELF
//
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