ID A0A287IK43_HORVV Unreviewed; 499 AA.
AC A0A287IK43;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Glutamate decarboxylase {ECO:0000256|ARBA:ARBA00012421, ECO:0000256|RuleBase:RU361171};
DE EC=4.1.1.15 {ECO:0000256|ARBA:ARBA00012421, ECO:0000256|RuleBase:RU361171};
OS Hordeum vulgare subsp. vulgare (Domesticated barley).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Hordeinae; Hordeum.
OX NCBI_TaxID=112509 {ECO:0000313|EnsemblPlants:HORVU.MOREX.r3.2HG0171750.1, ECO:0000313|Proteomes:UP000011116};
RN [1] {ECO:0000313|Proteomes:UP000011116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Morex {ECO:0000313|Proteomes:UP000011116};
RX PubMed=23075845; DOI=10.1038/nature11543;
RG The International Barley Genome Sequencing Consortium;
RA Mayer K.F., Waugh R., Brown J.W., Schulman A., Langridge P., Platzer M.,
RA Fincher G.B., Muehlbauer G.J., Sato K., Close T.J., Wise R.P., Stein N.;
RT "A physical, genetic and functional sequence assembly of the barley
RT genome.";
RL Nature 491:711-716(2012).
RN [2] {ECO:0000313|EnsemblPlants:HORVU.MOREX.r3.2HG0171750.1}
RP IDENTIFICATION.
RC STRAIN=subsp. vulgare
RC {ECO:0000313|EnsemblPlants:HORVU.MOREX.r3.2HG0171750.1};
RG EnsemblPlants;
RL Submitted (JAN-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + L-glutamate = 4-aminobutanoate + CO2;
CC Xref=Rhea:RHEA:17785, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:59888; EC=4.1.1.15;
CC Evidence={ECO:0000256|RuleBase:RU361171};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR602129-50, ECO:0000256|RuleBase:RU000382};
CC -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC {ECO:0000256|RuleBase:RU000382}.
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DR AlphaFoldDB; A0A287IK43; -.
DR PaxDb; 4513-MLOC_73968-2; -.
DR EnsemblPlants; HORVU.MOREX.r3.2HG0171750.1; HORVU.MOREX.r3.2HG0171750.1; HORVU.MOREX.r3.2HG0171750.
DR Gramene; HORVU.MOREX.r2.2HG0141870.1; HORVU.MOREX.r2.2HG0141870.1; HORVU.MOREX.r2.2HG0141870.
DR Gramene; HORVU.MOREX.r3.2HG0171750.1; HORVU.MOREX.r3.2HG0171750.1; HORVU.MOREX.r3.2HG0171750.
DR OrthoDB; 2783360at2759; -.
DR Proteomes; UP000011116; Chromosome 2H.
DR ExpressionAtlas; A0A287IK43; baseline.
DR GO; GO:0004351; F:glutamate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0006536; P:glutamate metabolic process; IEA:InterPro.
DR Gene3D; 3.90.1150.160; -; 1.
DR Gene3D; 4.10.280.50; -; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR010107; Glutamate_decarboxylase.
DR InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR NCBIfam; TIGR01788; Glu-decarb-GAD; 1.
DR PANTHER; PTHR43321; GLUTAMATE DECARBOXYLASE; 1.
DR PANTHER; PTHR43321:SF13; GLUTAMATE DECARBOXYLASE; 1.
DR Pfam; PF00282; Pyridoxal_deC; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Decarboxylase {ECO:0000256|RuleBase:RU361171};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000382};
KW Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW ECO:0000256|RuleBase:RU000382};
KW Reference proteome {ECO:0000313|Proteomes:UP000011116}.
FT MOD_RES 277
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ SEQUENCE 499 AA; 55731 MW; E5DF85EFEBA999B7 CRC64;
MVLTHVQSDE AAASAAVFAS RYVQEPVPSY ELGEKSISKD AAYQIIHDEL LLDGSPRLNL
ASFVTTWMEP ECDRLILEGM NKNYADMDEY PVTTELQNRC VNIIARLFNA PVGTGETAVG
VGTVGSSEAI MLAGLAFKRR WQNRRKAEGK PHDKPNIVTG ANVQVCWEKF ARYFEVELKE
VKLSEGCYVM DPDKAVEMVD ENTICVAAIL GSTLTGEFED VKRLNDLLVA KNKQTRWDTP
IHVDAASGGF IAPFLYPELE WDFRLPLVKS INVSGHKYGL VYPGVGWVIW RNREDLPDEL
IFHINYLGAD QPTFTLNFSK GSSQIIAQYY QFLRLGFEGY KNVMENCVES ARTLREGLLR
TGRFDVISKE DGVPLVAFTF RGIRDGSPAF KLSANLRRFG WIVPAYTMPA NLEHMTVLRV
VVREDFGRPL AERFLSHVRM ALSELDLAAK GPVPKMRLTI ELGPARSAEE EASVRVVKRE
AVSGHRSVSL VSGKTKGVC
//
