ID A0A287LF81_HORVV Unreviewed; 428 AA.
AC A0A287LF81;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=CBS domain-containing protein {ECO:0000259|PROSITE:PS51371};
OS Hordeum vulgare subsp. vulgare (Domesticated barley).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Hordeinae; Hordeum.
OX NCBI_TaxID=112509 {ECO:0000313|EnsemblPlants:HORVU.MOREX.r3.3HG0283530.1, ECO:0000313|Proteomes:UP000011116};
RN [1] {ECO:0000313|Proteomes:UP000011116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Morex {ECO:0000313|Proteomes:UP000011116};
RX PubMed=23075845; DOI=10.1038/nature11543;
RG The International Barley Genome Sequencing Consortium;
RA Mayer K.F., Waugh R., Brown J.W., Schulman A., Langridge P., Platzer M.,
RA Fincher G.B., Muehlbauer G.J., Sato K., Close T.J., Wise R.P., Stein N.;
RT "A physical, genetic and functional sequence assembly of the barley
RT genome.";
RL Nature 491:711-716(2012).
RN [2] {ECO:0000313|EnsemblPlants:HORVU.MOREX.r3.3HG0283530.1}
RP IDENTIFICATION.
RC STRAIN=subsp. vulgare
RC {ECO:0000313|EnsemblPlants:HORVU.MOREX.r3.3HG0283530.1};
RG EnsemblPlants;
RL Submitted (JAN-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|ARBA:ARBA00009476}.
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DR AlphaFoldDB; A0A287LF81; -.
DR EnsemblPlants; HORVU.MOREX.r3.3HG0283530.1; HORVU.MOREX.r3.3HG0283530.1; HORVU.MOREX.r3.3HG0283530.
DR Gramene; HORVU.MOREX.r3.3HG0283530.1; HORVU.MOREX.r3.3HG0283530.1; HORVU.MOREX.r3.3HG0283530.
DR Proteomes; UP000011116; Chromosome 3H.
DR ExpressionAtlas; A0A287LF81; baseline.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd00400; Voltage_gated_ClC; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000011116};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00023303}.
FT DOMAIN 278..334
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 351..415
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 428 AA; 46446 MW; 982E3CCEB240D439 CRC64;
MSELPLYLLL GVFCGVVSIT LSRCTALTMD MVEHLQKTTG LPMAVSPALG GLIVGLLALA
YPEVLYWGFE NVDILLESRP FTSGLSAAVL VQLIGVKILA TSLCRAFGLV GGYYAPSLFI
GAATGMAYGK FMRFTFTGSE ALFHVPFLDV ASPQAYGLVG MAATLAGVCK VPLTSVLLLF
ELTQDYRIVL PLLGAVGLSS WIASSQRFST SSKGKPGSLE EKTSTIEEAQ NVPTQTQQLT
SVDSVDATAE LCKLESSLCV YDARDDNVLE NLTVAETMKT RYISVSLKTP VVEALNLMLV
EKQPFVMITE SNKSPLGLLT VKDFQDFCKN AKSTRMQPEV DECLVSHVCG TVRCKIWSVT
PQMPLTAAEK IMDSHGVDQV PVVSEHVNHQ DGGILIGFVD RECITIARRA LAAKEFFSFT
SEIRREER
//
