ID A0A288TXX0_9CAUD Unreviewed; 319 AA.
AC A0A288TXX0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Thymidylate synthase {ECO:0000256|ARBA:ARBA00015931};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN ORFNames=EFP01_133 {ECO:0000313|EMBL:APZ82060.1};
OS Enterococcus phage EFP01.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Herelleviridae; Brockvirinae; Schiekvirus; Schiekvirus EFP01.
OX NCBI_TaxID=1926594 {ECO:0000313|EMBL:APZ82060.1, ECO:0000313|Proteomes:UP000224269};
RN [1] {ECO:0000313|EMBL:APZ82060.1, ECO:0000313|Proteomes:UP000224269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Song W.-J., Kurnit D.M.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC {ECO:0000256|ARBA:ARBA00009972}.
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DR EMBL; KY549443; APZ82060.1; -; Genomic_DNA.
DR Proteomes; UP000224269; Genome.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR InterPro; IPR020940; Thymidylate_synthase_AS.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..318
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT ACT_SITE 193
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10016"
SQ SEQUENCE 319 AA; 36520 MW; 61261FB6C9E67CE9 CRC64;
MSFDNIYADL VLAIKEKGIL QNPDEVRAHY EDGEPAPAYA IEGVSFEITP DMGLPILKSK
FVGSKWAFTE LEWIWQAMSN DVKWLQERGV TIWNEWVQED GTIGKAYGWQ LRNKERFVAS
GDGITLAKNR LEDCPITKFV PLDGYNLGSY QPYIKLNQVE AVIAQLKNNP SSRRIMTTLW
DVEDLDDMAL EPCVWATHWT VQNGKLNLHV KQRSSDCCLG LPFNVLQYHA LQVVMAKVSG
LELGTMFWNI DNAHIYDRHM ERAVEQVTAP MTEEVLNAEP KLVLPWEEAD MTNFFECPLS
ELKVEGYKHN GRFNYEVAI
//
