ID A0A290ZNP1_9RHOO Unreviewed; 775 AA.
AC A0A290ZNP1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=CCZ27_12225 {ECO:0000313|EMBL:ATE60606.1};
OS Thauera sp. K11.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC Thauera.
OX NCBI_TaxID=2005884 {ECO:0000313|EMBL:ATE60606.1, ECO:0000313|Proteomes:UP000217984};
RN [1] {ECO:0000313|EMBL:ATE60606.1, ECO:0000313|Proteomes:UP000217984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K11 {ECO:0000313|EMBL:ATE60606.1,
RC ECO:0000313|Proteomes:UP000217984};
RA Xi L., Qiao N.;
RT "Thauera phenolivorans sp. nov., a phenol derivative-degrading bacterium
RT isolated from activated sludge and an emended description of the genus
RT Thauera.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP023439; ATE60606.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A290ZNP1; -.
DR REBASE; 221936; TspK11ORF12215P.
DR KEGG; thk:CCZ27_12225; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000217984; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000217984};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 280..352
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 438..567
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 775 AA; 84600 MW; EDC67C1F340F665D CRC64;
MTDPSPGLRG TIGHTLPSDL RGQLEAAVRA AREAAEAGAQ SALFQLGVAE DEAPAHLDEP
QRALRRRLRA HARVLGDALG ADGIQGVQRL VWETAYEHWH RMLFARFLAE RHLLIWEGEV
SVTLDECHEL AGSSGSALRV GSGWELAGRL AERMLPQLFR ADSPVLALRF APEYQQALER
LLAGLPRTVF LASDSLGWAY QFWQGKRKEE VNASQMKVGA DELPAVTQLF TEPYMVEYLL
HNTVGALWRA SHPELAKRLA LRYLVTPNAG GSAQPSKSTI GRFGSLKLMD PCCGSGHFLV
AALHLLVPMR VLAEGLSVRN AVDSVLAQNL FGVELDARCV EIAAFALALA AWSYPDEEGC
PLGFRPLPEL NLACAGRAPS RRRSGSAPLR GSLLPVQFDS AQWEEALAKE DSRGAGDAEG
EEQFIAAQGF ARAVALLRER YDVVVTNPPF LGRGRMCDAL REFVEAQFYD ARHDLGAVFL
EYCLKLAKPE GRVGCVLQQS WLFAGSYGAH RRAILQQAAL RSVANLGEGA FRSVDAAGAF
PSLLVFERLV PEVDSHIAVV DVAIHRTAEE KAAALGAAVP DALAFAQVSG SPDYLIALTQ
GGSLPPLSEF ATPYVGLQTS DYPRYCRFFW ELPLRTPDWE YMQESPEETG KLTGLSSLFY
WQQGSGDLMS SGLAYIRGQA AWGKKGVAVS RMRQLEAGPY LGNFYNQTTA AIIPRDESLL
PAVMAFCSSD EYTEAVHEID RRICVANAAL GRVGFDLPRW QAEAERQFPN GLPAT
//
