ID A0A290ZUW4_9RHOO Unreviewed; 857 AA.
AC A0A290ZUW4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=CCZ27_20355 {ECO:0000313|EMBL:ATE62808.1};
OS Thauera sp. K11.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC Thauera.
OX NCBI_TaxID=2005884 {ECO:0000313|EMBL:ATE62808.1, ECO:0000313|Proteomes:UP000217984};
RN [1] {ECO:0000313|EMBL:ATE62808.1, ECO:0000313|Proteomes:UP000217984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K11 {ECO:0000313|EMBL:ATE62808.1,
RC ECO:0000313|Proteomes:UP000217984};
RA Xi L., Qiao N.;
RT "Thauera phenolivorans sp. nov., a phenol derivative-degrading bacterium
RT isolated from activated sludge and an emended description of the genus
RT Thauera.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP023439; ATE62808.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A290ZUW4; -.
DR KEGG; thk:CCZ27_20355; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000217984; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR025589; Toprim_C_rpt.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR Pfam; PF13342; Toprim_Crpt; 2.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ATE62808.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000217984};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 3..136
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT REGION 821..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 95239 MW; C8BF0829105ADC9B CRC64;
MSKQLIIAEK PSVAQDIARA LGGFTKEKDY YESEHYVLSS AVGHLLELAV PEEFEVKRGK
WTFAHLPVIP PHFAVKPIEK TEDRLKLLTR LIKRKDVTGL VNACDAGREG ELIFNFIAQH
AGTRKPTQRL WLQSMTPQAI RDGFAHLRTA QDVEGLRNAA VCRAESDWLI GINGTRAMTA
FNSRTGGFHL TTVGRVQTPT LALVVEREEK IRKFRPRDYW ELEATFGCTA GRYAGRWFDE
KFRKPEGDEH ATAFRLWDKA RAEAIRAKCD GKPGVVTEEA KPSTQLSPLL FDLTSLQREA
NGRFGFSARV TLQLAQALYE KHKVLTYPRT DSRALPEDYV GTVKDVMRTL PDQYAPFAGE
ITRQGWVKPN KRIFNNAKIS DHFAIIPTGT LPKSLSEAEH KIYDLVTRRF LSVFYPAAEY
QITTRITRVE DEAFKTEGKV LVNPGWLAVY GKEATAEAKD DKEGGSPQLV PVKQGETVST
EEILLKALQT KPPARFNEAT LLSAMEGAGK MVDDEELRAA MAERGLGTPA TRAQIIEGLI
TEQYIHREGR ELIPSAKAFS LITLLKGLGV TALTSPELTG GWEYKLAQME HGKLSREAFM
QEIAEMAREV VERAKRYESD TVPGDFVTLR TPCPKCGGVV KENYKKFACQ SCDWSTWKIV
AGRQFEIDEI ETLLRDGKVG PLLGFRNKMG RLFNADIVLN DDKQPAFDFG QPKEGEEAEA
VDFSEQEAVG ACPKCAGRVF EHGMAYVCEK SVGPAKSCDF RSGKVILQQP IEREQMARLL
AEGKTDLLKG FVSARTRRKF SAFLVRGKDG KVGFEFEAKA PKAAAGKTAT AATEPAGASA
AEEEKKPAPR KRPGKAS
//
