ID A0A291GJJ1_9MICO Unreviewed; 406 AA.
AC A0A291GJJ1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Acetyl-CoA C-acyltransferase {ECO:0000313|EMBL:ATG50519.1};
GN ORFNames=CFK38_02510 {ECO:0000313|EMBL:ATG50519.1};
OS Brachybacterium vulturis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Dermabacteraceae;
OC Brachybacterium.
OX NCBI_TaxID=2017484 {ECO:0000313|EMBL:ATG50519.1, ECO:0000313|Proteomes:UP000218165};
RN [1] {ECO:0000313|Proteomes:UP000218165}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VM2412 {ECO:0000313|Proteomes:UP000218165};
RA Tak E.J., Bae J.-W.;
RT "Brachybacterium sp. VM2412.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP023563; ATG50519.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A291GJJ1; -.
DR KEGG; brz:CFK38_02510; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000218165; Chromosome.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF134; BETA-KETOACYL COA THIOLASE FADA3-RELATED; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:ATG50519.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000218165};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:ATG50519.1}.
FT DOMAIN 6..273
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 282..404
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT REGION 219..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 89
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 360
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 392
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 406 AA; 41641 MW; 27D012AE5E6CE584 CRC64;
MSEAFLVGGA RTPVGRYGGA LSSVRPDDLA ALVVRAAVER AGIDPAAVDE VILGNANGAG
EENRNVARMA WLLCGYPDAV PGITVNRLCA SGMSAILMAS QMIRAGDADL VVAGGVESMS
RAPWVMEKPA QPFARPGAVV DTSIGWRFTN PAFLSGQCSR DGKATFSMPE TAEEVARRYR
TSREDCDAFA ARSHQRALAA IDAGRFSAEI APVTVADRKG RESVVQDDEG PRPGSTPEVL
AGLRPVVPGG SVVTAGNASS LNDGASAIVV ASEAAVDKFG LRPRARVLAG ASAGLAPEIM
GMGPVPSTRK VLERTGRAVE DLAAVELNEA FASQSLASMR ELGLDPATVN NDGGAIALGH
PLGSSGSRIA LTLLGRLERE ASPGDLGLAT MCVGVGQGSA MLVEAV
//
