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Database: UniProt
Entry: A0A291GKY6_9MICO
LinkDB: A0A291GKY6_9MICO
Original site: A0A291GKY6_9MICO 
ID   A0A291GKY6_9MICO        Unreviewed;       734 AA.
AC   A0A291GKY6;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   08-MAY-2019, entry version 8.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:ATG50730.1};
GN   ORFNames=CFK38_03745 {ECO:0000313|EMBL:ATG50730.1};
OS   Brachybacterium sp. VM2412.
OC   Bacteria; Actinobacteria; Micrococcales; Dermabacteraceae;
OC   Brachybacterium.
OX   NCBI_TaxID=2017484 {ECO:0000313|EMBL:ATG50730.1, ECO:0000313|Proteomes:UP000218165};
RN   [1] {ECO:0000313|EMBL:ATG50730.1, ECO:0000313|Proteomes:UP000218165}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VM2412 {ECO:0000313|EMBL:ATG50730.1,
RC   ECO:0000313|Proteomes:UP000218165};
RA   Tak E.J., Bae J.-W.;
RT   "Brachybacterium sp. VM2412.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; CP023563; ATG50730.1; -; Genomic_DNA.
DR   KEGG; brz:CFK38_03745; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000218165; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000218165};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296}.
FT   DOMAIN      363    541       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      544    624       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   734 AA;  75733 MW;  1AE144B98EF3472A CRC64;
     MSSYTEHVTR VLTEDREHPG LGTVAVLTFA PPEGEERRPA TLGPRSIEAV TGALAAALDR
     AEAGEIQAVA MTGTGRAFLA GADLSMFADP AAVAQVETMT RAMHDLQIRV RTSPVPVLAH
     LNAVALGGGL EVALMADVRT AAPGVRGLGT PETSLGILPG WGGTTLLQSV VGAETAVRMI
     LEDPARETQL GAEQALENGL VDELAADLDE ALDQFAALVA AHIDLDETDA DVVDPALAAT
     AADSPADAPG AWAGREAPLP GADTPEAEAL LDALDAPHGS AETRRAWASR LEAQGAPAVG
     RALALLQALP GSTLPEALDR EAAALAELVR SDAAAASMYS AELLRRGKPG RSPVDGAREI
     RRVGVAGAGL MASQIAAQLA LGLQVPVVMR DLDTETAAKG LAAAQDVIAR TAARGMLDEA
     AAAQIAENLS ATTDLQELAG CDLVLEAVPE VLAIKQSVFA ELEGVLAEDA LLVTNTSSLS
     VAQMAEDLAH PERVMGLHFF NPVAKMPLVE VIHTEATDEA TLATGLEVVR RLKKFAVRSA
     DAPGFIVNRL LFRVLGAVLA SVDAGADPDE VDASLDALGL PMRPFALLDL VGLAVADHVG
     QVLAAELGDR FHASPGLSAM VEKQARFTEP SRTAVHPTVS PTVAEVCGRD PSGAAAAPVG
     DALLETVQDG LAQEIALMLE SGVVERPEQV DLALILGAGF PRHRGGVTAY LDSSGASQRV
     NGRTFHGEMF TGRG
//
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