ID A0A291GPQ9_9MICO Unreviewed; 233 AA.
AC A0A291GPQ9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Putative pterin-4-alpha-carbinolamine dehydratase {ECO:0000256|ARBA:ARBA00021735};
DE EC=4.2.1.96 {ECO:0000256|ARBA:ARBA00013252};
GN ORFNames=CFK38_11140 {ECO:0000313|EMBL:ATG52012.1};
OS Brachybacterium vulturis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Dermabacteraceae;
OC Brachybacterium.
OX NCBI_TaxID=2017484 {ECO:0000313|EMBL:ATG52012.1, ECO:0000313|Proteomes:UP000218165};
RN [1] {ECO:0000313|Proteomes:UP000218165}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VM2412 {ECO:0000313|Proteomes:UP000218165};
RA Tak E.J., Bae J.-W.;
RT "Brachybacterium sp. VM2412.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin =
CC (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96;
CC Evidence={ECO:0000256|ARBA:ARBA00001554};
CC -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine dehydratase
CC family. {ECO:0000256|ARBA:ARBA00006472}.
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DR EMBL; CP023563; ATG52012.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A291GPQ9; -.
DR KEGG; brz:CFK38_11140; -.
DR OrthoDB; 15077at2; -.
DR Proteomes; UP000218165; Chromosome.
DR GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:InterPro.
DR Gene3D; 3.10.180.10; 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1; 1.
DR Gene3D; 3.30.1360.20; Transcriptional coactivator/pterin dehydratase; 1.
DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR InterPro; IPR041581; Glyoxalase_6.
DR InterPro; IPR036428; PCD_sf.
DR InterPro; IPR001533; Pterin_deHydtase.
DR Pfam; PF18029; Glyoxalase_6; 1.
DR Pfam; PF01329; Pterin_4a; 1.
DR SUPFAM; SSF55248; PCD-like; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000218165}.
FT DOMAIN 120..219
FT /note="Glyoxalase-like"
FT /evidence="ECO:0000259|Pfam:PF18029"
SQ SEQUENCE 233 AA; 24626 MW; 8AF80DFE70C1E233 CRC64;
MEMLGGTQIA AARLTQWCQL AQGLHARYQI DDFAAGGRFL VDIGEAGAEL GHQPIVSMDA
RHVDLKLVSD DAIFRDGETE HVAQWVTQKD LDLAARITEI AARHELSADV AAVSHVELGL
DNSQSATIAP VWAALLTGDP DAQGRGTPSD EVRDATGRVP NLWFGDVPQA DGQRFHLEVY
VTPEVATERI AAAVAAGGTV VDDSQAPSLV VLADQDGNRG VVCAPAPMAS TDD
//
