ID A0A291JIN7_9STAP Unreviewed; 429 AA.
AC A0A291JIN7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Na+/H+ antiporter NhaC family protein {ECO:0000313|EMBL:PTK59492.1};
DE SubName: Full=Sodium:proton antiporter {ECO:0000313|EMBL:ATH59420.1};
GN ORFNames=BJD96_03225 {ECO:0000313|EMBL:ATH59420.1}, BUZ60_00710
GN {ECO:0000313|EMBL:RIO45244.1}, BUZ61_05705
GN {ECO:0000313|EMBL:PTK59492.1}, CD130_03100
GN {ECO:0000313|EMBL:PNZ99800.1};
OS Staphylococcus nepalensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=214473 {ECO:0000313|EMBL:ATH59420.1, ECO:0000313|Proteomes:UP000217956};
RN [1] {ECO:0000313|Proteomes:UP000240400, ECO:0000313|Proteomes:UP000265695}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SNUC 4025 {ECO:0000313|EMBL:RIO45244.1,
RC ECO:0000313|Proteomes:UP000265695}, and SNUC 4337
RC {ECO:0000313|EMBL:PTK59492.1, ECO:0000313|Proteomes:UP000240400};
RX PubMed=28066335; DOI=.3389/fmicb.2016.01990;
RA Naushad S., Barkema H.W., Luby C., Condas L.A., Nobrega D.B., Carson D.A.,
RA De Buck J.;
RT "Comprehensive Phylogenetic Analysis of Bovine Non-aureus Staphylococci
RT Species Based on Whole-Genome Sequencing.";
RL Front. Microbiol. 7:1990-1990(2016).
RN [2] {ECO:0000313|EMBL:ATH59420.1, ECO:0000313|Proteomes:UP000217956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JS1 {ECO:0000313|EMBL:ATH59420.1,
RC ECO:0000313|Proteomes:UP000217956};
RA Nam Y.-D., Kang J., Chung W.-H.;
RT "Complete genome sequence of Staphylococcus nepalensis JS1.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:PNZ99800.1, ECO:0000313|Proteomes:UP000236280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15150 {ECO:0000313|EMBL:PNZ99800.1,
RC ECO:0000313|Proteomes:UP000236280};
RA Cole K., Golubchik T., Russell J., Foster D., Llewelyn M., Wilson D.,
RA Crook D., Paul J.;
RT "Draft genome sequences of 64 type strains of genus Staph aureus.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:PTK59492.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SNUC 4337 {ECO:0000313|EMBL:PTK59492.1};
RA Keele B.F.;
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:RIO45244.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SNUC 4025 {ECO:0000313|EMBL:RIO45244.1};
RA Parvin R., Begum J.A., Chowdhury E.H., Islam M.R., Harder T.;
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter
CC family. {ECO:0000256|ARBA:ARBA00038435}.
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DR EMBL; CP017460; ATH59420.1; -; Genomic_DNA.
DR EMBL; PPRR01000040; PNZ99800.1; -; Genomic_DNA.
DR EMBL; PZHR01000021; PTK59492.1; -; Genomic_DNA.
DR EMBL; QXVN01000001; RIO45244.1; -; Genomic_DNA.
DR KEGG; snl:BJD96_03225; -.
DR OrthoDB; 9790605at2; -.
DR Proteomes; UP000217956; Chromosome.
DR Proteomes; UP000236280; Unassembled WGS sequence.
DR Proteomes; UP000240400; Unassembled WGS sequence.
DR Proteomes; UP000265695; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR PANTHER; PTHR33451; MALATE-2H(+)/NA(+)-LACTATE ANTIPORTER; 1.
DR PANTHER; PTHR33451:SF5; NA+_H+ ANTIPORTER-RELATED; 1.
DR Pfam; PF03553; Na_H_antiporter; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 34..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 73..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..208
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
FT DOMAIN 237..422
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 429 AA; 45077 MW; B0D37E0A198016BD CRC64;
MTETKKGNAW ALVPLIIFVG IFLGVGLITG DFSIMPLNVA IVVASIIGLL MNRKETFQKK
VDVFTKGAGH SNIILMMLIF LLAGAFSQTT EDMGGVTSTV NLGLSFIPEN LIIVGLFIIC
MFVSLSMGTS VGTVAAIAPV GFGLSQATDV SAALTMATVV GGAMFGDNLS MISDTTIAAV
RTQKTKMSDK FKVNIKIVLP GAIFTMIVLW FLTHSAQIDA TKAYDYNFIK VIPYILVLIL
ALAGINVIIV LIGGTVLSAI IGLVDGSFSW SGLLSSVSKG IIGMEDIAII ALLIGGLVAL
IQHNGGITWL LNFVRNRVKS KRGAELGIAG LVSAADISTA NNTISILMAG PLAKNIADEY
DIDSRKSASI LDIFASCFQG LLPYSPQVIA AAGVASISPI ALAPYAIYPI ILGVCGLIAI
FFRIPKLNK
//
