ID A0A291LEP2_9CAUD Unreviewed; 506 AA.
AC A0A291LEP2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
OS Aeromonas phage AS-szw.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Straboviridae; Emmerichvirinae; Ceceduovirus; Ceceduovirus aszj.
OX NCBI_TaxID=2026114 {ECO:0000313|EMBL:ATI17484.1, ECO:0000313|Proteomes:UP000230211};
RN [1] {ECO:0000313|EMBL:ATI17484.1, ECO:0000313|Proteomes:UP000230211}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Chen L., Yuan S., Ma Y.;
RT "In vitro design and evaluation of phage cocktails against multidrug-
RT resistant Aeromonas salmonicida.";
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
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DR EMBL; MF498773; ATI17484.1; -; Genomic_DNA.
DR Proteomes; UP000230211; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 107..276
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 355..485
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 506 AA; 59111 MW; E6F619417F8E8BE7 CRC64;
MNFYTSVWLD GNTIYDRYFD DNGNDKIRKV RYEPTMYRHV GDHIDTPYRD IFGKRCLPKK
LDSVSEARKW FKDMQSMGKD VLGMDNYTFQ YISDTYGSNV YYDYTYLDIM FLDIEVPTDG
PFPQAEETKY EIDTIQIYST KSKKYYIWTI REWDACKSIL DKKVLDDVEY VLCGSEKEIL
IKFMHFFCTN TPHYLSGWNS EFFDIPYIMG RIKKVLGEKF IHKLSPFGET TEITQKDDND
EDYTTYTIQG VNCVDFMAAY KKFTFTTRPN YKLDTIAEAE LKTNKVEMTY KTYLMFAEKD
PQTYIDYSIR DVEIIKRLEE TLSLIFLIAS VSYYASINAP DVFSPLKTWD AIIYNSLLAN
NVIIPENKHA QRSKFAGAYV KDPIPGLYEW LISFDLTSLY PHEIMGKNIS PETLVDQVDF
PRILVKDRMV PDIEGMGLVN KTFDVPHEGK YSVAPNGVRY RNDKRGFLPI EVEKVFVQRK
QAKTEEFKAD ALATRAAAIL AKRNDK
//
