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Database: UniProt
Entry: A0A291P4E7_9GAMM
LinkDB: A0A291P4E7_9GAMM
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ID   A0A291P4E7_9GAMM        Unreviewed;       429 AA.
AC   A0A291P4E7;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   13-FEB-2019, entry version 6.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138,
GN   ECO:0000313|EMBL:ATJ81735.1};
GN   ORFNames=BEI_0748 {ECO:0000313|EMBL:ATJ81735.1};
OS   Halomonas beimenensis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=475662 {ECO:0000313|EMBL:ATJ81735.1, ECO:0000313|Proteomes:UP000219993};
RN   [1] {ECO:0000313|EMBL:ATJ81735.1, ECO:0000313|Proteomes:UP000219993}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NTU-111 {ECO:0000313|EMBL:ATJ81735.1,
RC   ECO:0000313|Proteomes:UP000219993};
RX   PubMed=29026163;
RA   Chen Y.H., Lin S.S., Shyu Y.T.;
RT   "Revealing the Saline Adaptation Strategies of the Halophilic
RT   Bacterium Halomonas beimenensis through High-throughput Omics and
RT   Transposon Mutagenesis Approaches.";
RL   Sci. Rep. 7:13037-13037(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
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DR   EMBL; CP021435; ATJ81735.1; -; Genomic_DNA.
DR   KEGG; hbe:BEI_0748; -.
DR   KO; K01945; -.
DR   BioCyc; GCF_002549795:BEI_RS03755-MONOMER; -.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000219993; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000219993};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:ATJ81735.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138};
KW   Reference proteome {ECO:0000313|Proteomes:UP000219993}.
FT   DOMAIN      109    316       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
SQ   SEQUENCE   429 AA;  45403 MW;  46F9611D7628FDC2 CRC64;
     MKVLIIGGGG REHALAWKVA QSPRVETVYV APGNAGTARE PGLENVAIGA EDLDGLVRFA
     RDEAVELTIV GPEAPLVAGV VDRFREAGLA IFGPTAGAAQ LEGSKAFTKD FLARHAIPSA
     EYRTFVAVEP ALAYLAEKGA PIVIKADGLA AGKGVIVAMT QEEAEAAVRD MLEANAFGDA
     GARVVIEDFL EGEEASFIVM VDGDTVLPMA TSQDHKRAYD DDQGPNTGGM GAYSPAPVVT
     GEVFERIMDR VIRPTVQGMA EEGHPYTGFL YAGLMIDDQG NPRVIEYNCR FGDPETQPIM
     LRLTSDLAEL CLAGARGELA GHRCDWDERA AVWVVMAAGG YPGGYRKGDA IQGLVAAEST
     GCKVFHAGTA EGEDGEVVTA GGRVLCVTAL GEGVFAAREL AYRGVAEIHW PDAFYRRDIA
     HRAIAREQG
//
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