GenomeNet

Database: UniProt
Entry: A0A291P739_9GAMM
LinkDB: A0A291P739_9GAMM
Original site: A0A291P739_9GAMM 
ID   A0A291P739_9GAMM        Unreviewed;       446 AA.
AC   A0A291P739;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   18-SEP-2019, entry version 7.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   ORFNames=BEI_1701 {ECO:0000313|EMBL:ATJ82688.1};
OS   Halomonas beimenensis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=475662 {ECO:0000313|EMBL:ATJ82688.1, ECO:0000313|Proteomes:UP000219993};
RN   [1] {ECO:0000313|EMBL:ATJ82688.1, ECO:0000313|Proteomes:UP000219993}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NTU-111 {ECO:0000313|EMBL:ATJ82688.1,
RC   ECO:0000313|Proteomes:UP000219993};
RX   PubMed=29026163;
RA   Chen Y.H., Lin S.S., Shyu Y.T.;
RT   "Revealing the Saline Adaptation Strategies of the Halophilic
RT   Bacterium Halomonas beimenensis through High-throughput Omics and
RT   Transposon Mutagenesis Approaches.";
RL   Sci. Rep. 7:13037-13037(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CP021435; ATJ82688.1; -; Genomic_DNA.
DR   KEGG; hbe:BEI_1701; -.
DR   KO; K00012; -.
DR   BioCyc; GCF_002549795:BEI_RS08430-MONOMER; -.
DR   Proteomes; UP000219993; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000219993};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124}.
FT   DOMAIN      320    424       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    266    266       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      30     30       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      86     86       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     121    121       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     158    158       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     269    269       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     334    334       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   446 AA;  48838 MW;  AEDFC02CF7A0D1A1 CRC64;
     MKITIFGTGY VGLVTGTCLA DVGHDVVCMD VDADKVARLE AGEIPIYEPG LETLVRHNMA
     EGRLRFTTDA EAAVRFGTLQ FIAVGTPPDE DGSADLQYVL AVAETIGRHM TDEVVVVDKS
     TVPVGTADRV RDTIARVLDE RGESLAFEVC SNPEFLKEGN AIEDFTQGAR IIVGTESEWV
     KGLMRECYGP YIRLQEKLMF MDVRAAELTK YAANAMLATK ISFMNEIANL AERLGADVEQ
     VRRGIGSDPR IGYHFIYPGC GYGGSCFPKD VQALARTAGD VDYPADLLQA VEAVNHRQKQ
     TLFAKLSRAF DGQLAGRTIA VWGLSFKPNT DDMRDAPSRT LMEALWAAGA RVRAYDPEAM
     DECRRIYGPR DDLALVADRQ QAVAGADALV ICTEWKVFRT VDFAWLKDEL AMPVIVDGRN
     LFDPATVQGH GLMYYAVGRG NSLQGA
//
DBGET integrated database retrieval system