ID   A0A292YQL0_9BACL        Unreviewed;       242 AA.
AC   A0A292YQL0;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=CRISPR-associated endoribonuclease {ECO:0000256|PIRNR:PIRNR005054};
GN   ORFNames=EFBL_2332 {ECO:0000313|EMBL:GAX90694.1};
OS   Effusibacillus lacus.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Alicyclobacillaceae;
OC   Effusibacillus.
OX   NCBI_TaxID=1348429 {ECO:0000313|EMBL:GAX90694.1, ECO:0000313|Proteomes:UP000217785};
RN   [1] {ECO:0000313|Proteomes:UP000217785}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=skLN1 {ECO:0000313|Proteomes:UP000217785};
RA   Watanabe M., Kojima H., Fukui M.;
RT   "Draft genome sequence of Effusibacillus lacus strain skLN1.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat), is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain sequences complementary to
CC       antecedent mobile elements and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA).
CC       {ECO:0000256|PIRNR:PIRNR005054}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE
CC       family. {ECO:0000256|ARBA:ARBA00005937, ECO:0000256|PIRNR:PIRNR005054}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAX90694.1}.
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DR   EMBL; BDUF01000061; GAX90694.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A292YQL0; -.
DR   OrthoDB; 9797488at2; -.
DR   Proteomes; UP000217785; Unassembled WGS sequence.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   CDD; cd21140; Cas6_I-like; 1.
DR   Gene3D; 3.30.70.1890; -; 1.
DR   Gene3D; 3.30.70.1900; -; 1.
DR   InterPro; IPR049435; Cas_Cas6_C.
DR   InterPro; IPR010156; CRISPR-assoc_prot_Cas6.
DR   InterPro; IPR045747; CRISPR-assoc_prot_Cas6_N_sf.
DR   NCBIfam; TIGR01877; cas_cas6; 1.
DR   PANTHER; PTHR36984; CRISPR-ASSOCIATED ENDORIBONUCLEASE CAS6 1; 1.
DR   PANTHER; PTHR36984:SF1; CRISPR-ASSOCIATED ENDORIBONUCLEASE CAS6 1; 1.
DR   Pfam; PF21350; Cas6_I-A; 1.
DR   Pfam; PF01881; Cas_Cas6_C; 1.
DR   PIRSF; PIRSF005054; PF1131; 1.
PE   3: Inferred from homology;
KW   Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW   Reference proteome {ECO:0000313|Proteomes:UP000217785};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          118..242
FT                   /note="CRISPR associated protein Cas6 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01881"
FT   ACT_SITE        29
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005054-50"
FT   ACT_SITE        41
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005054-50"
SQ   SEQUENCE   242 AA;  27811 MW;  443A1CF39516F7CF CRC64;
     MRFKITLEAV NDFVSLPLQH NEFIQAAIYS SLSPDFAAFL HDKGYRIDNR RFTLFAFSRI
     MGTYQILRER KQIHFSNPIQ LVVSSPVQEF IRDMAQLLLK DGFRIGSQYL RVTGMEIQEP
     KVEQEEIVVH TLSPVVAYST LLRPDGNKYT LYFEPGESDF RRIVTDNLLR KGRLIYGEEV
     DFHGVQVEPV GHYKRHIVMY KDSAIKGYSG KFRLKGDRRL LQTAIDAGLG SKNAMGFGLV
     EV
//