ID   A0A292YVN4_9PSEU        Unreviewed;      1092 AA.
AC   A0A292YVN4;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Dihydroxy-acid dehydratase {ECO:0000313|EMBL:GAY07982.1};
DE            EC=4.2.1.9 {ECO:0000313|EMBL:GAY07982.1};
GN   ORFNames=TOK_6175 {ECO:0000313|EMBL:GAY07982.1};
OS   Pseudonocardia sp. N23.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Pseudonocardia.
OX   NCBI_TaxID=1987376 {ECO:0000313|EMBL:GAY07982.1, ECO:0000313|Proteomes:UP000222857};
RN   [1] {ECO:0000313|EMBL:GAY07982.1, ECO:0000313|Proteomes:UP000222857}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N23 {ECO:0000313|EMBL:GAY07982.1,
RC   ECO:0000313|Proteomes:UP000222857};
RA   Yamamoto N., Saito Y., Inoue D., Sei K., Ike M.;
RT   "Characterization of newly isolated Pseudonocardia sp. N23 with high 1,4-
RT   dioxane-degrading ability.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the IlvD/Edd family.
CC       {ECO:0000256|ARBA:ARBA00006486}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAY07982.1}.
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DR   EMBL; BEGX01000009; GAY07982.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A292YVN4; -.
DR   Proteomes; UP000222857; Unassembled WGS sequence.
DR   GO; GO:0004160; F:dihydroxy-acid dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.30.80; IlvD/EDD C-terminal domain-like; 1.
DR   InterPro; IPR042096; Dihydro-acid_dehy_C.
DR   InterPro; IPR000581; DiOHA_6PGluconate_deHydtase.
DR   InterPro; IPR037237; IlvD/EDD_N.
DR   PANTHER; PTHR43183:SF1; HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED; 1.
DR   PANTHER; PTHR43183; HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED; 1.
DR   Pfam; PF00920; ILVD_EDD; 1.
DR   SUPFAM; SSF143975; IlvD/EDD N-terminal domain-like; 1.
DR   SUPFAM; SSF52016; LeuD/IlvD-like; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:GAY07982.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          509..537
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          579..598
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          922..959
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          994..1081
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1031..1058
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1092 AA;  116566 MW;  413D72F019A937A4 CRC64;
     MATARGRRPD GHAPGGSTMS PTDALRSAQW YSGDDRNAYI HRAWMRRGAP GDAFTGRPQI
     AIANTASDLT PCNRHLTEVA ASVRDGVLAA GGTPLELPVV SLGETLVRPT AMLWRNMAAM
     ATEEMLRANP IDGVVLLGGC DKTIPSLLMA AASVDLPAVV VPGGPMLTGT FQGKPLGCGT
     DVWRLSEEVR AGTLSTGDFT RSESSMIRSR GHCNTMGTAS TMALVAEALG TVVPGVAGTP
     APDSRLLESA HMTGRLAVEM VAADRRPSMF LTTASFHNAI VALAAIGGST NAVVHLLAIA
     GRAGVELTLD DVDRIGSRVP MLVDLQPAGR FLMEDLHRAG GLRAVLREVR DLLDPTALTV
     TGTPLVDGLD EATIWDPEVV RTRDNPMVAE GGIAVLRGSL APDGAVVKPA AASPHLLQHR
     GRAVVFDSIE DFNARVDDPD LDVDEDSVLV LRGCGPKGYP GMPEVANLPL PPKLLARGVR
     DMVRVCDGRM SGTAYGTVVL HVAPEAAAGG PRRSSITQDR CETARPHVRS SGGPTASALR
     HGVRVPGQHA LDDPVHPVAR QRLHEVDPHR DLVVGETARA PGDQLVGGGH DAGRHDDGAD
     VAAQDLVGQR NDGDLRDPRM LQQHTLHLDR RHVQPAAADQ RGVAVDEVDE PRVVGRRHVT
     GAQPTPTGQC PRRRTGVGDV ARHRRRAAQA QLADLPRAGG LLGVLATHLD AHPVPEPGPA
     DRQPVVPHAV ESLGVIVVDQ HDARRPTLGE PVDVHQLRTP ALADLRPDAP VERLAAGLPA
     VADPLQRGQV VGGELRGGAT VEDQGEDRRD QEHRRRAVAH HPVEGGVHVE LRLHDVGASR
     GQAAQQVRVA AGAGEERRER LVDAARPHPP RAHRLVAARH RPAMAQRHRL RTAGGTGREE
     PVGVVVTGER RLPDSRIRTL QQARRDVEEH RVTAARRGQQ PAEPRPVHDR RRLHETQDVG
     QLARDVAGVE RHADRAEAVR RVVGDVGLRG AVVVDQHADP VTRPDPGGRQ RRGGDGGPVR
     QLAVGPRDLA AGDETRCDQR RRVTDPRHPR REQLGDGLLR ARRVGPPEVP SGHSGYPTAT
     PFSTRSMYSM IP
//