ID A0A2A2EN74_9BIFI Unreviewed; 1084 AA.
AC A0A2A2EN74;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Leucine Rich repeats (2 copies) {ECO:0000313|EMBL:PAU70272.1};
GN ORFNames=B1400_0076 {ECO:0000313|EMBL:PAU70272.1};
OS Bifidobacterium italicum.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=1960968 {ECO:0000313|EMBL:PAU70272.1, ECO:0000313|Proteomes:UP000217986};
RN [1] {ECO:0000313|EMBL:PAU70272.1, ECO:0000313|Proteomes:UP000217986}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=70 {ECO:0000313|EMBL:PAU70272.1,
RC ECO:0000313|Proteomes:UP000217986};
RX PubMed=28837128; DOI=10.1038/ismej.2017.138;
RA Milani C., Mangifesta M., Mancabelli L., Lugli G.A., James K., Duranti S.,
RA Turroni F., Ferrario C., Ossiprandi M.C., van Sinderen D., Ventura M.;
RT "Unveiling bifidobacterial biogeography across the mammalian branch of the
RT tree of life.";
RL ISME J. 11:2834-2847(2017).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the internalin family.
CC {ECO:0000256|ARBA:ARBA00009432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAU70272.1}.
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DR EMBL; MVOG01000002; PAU70272.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2EN74; -.
DR Proteomes; UP000217986; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR Gene3D; 2.60.40.1080; -; 1.
DR Gene3D; 2.60.40.1220; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR003343; Big_2.
DR InterPro; IPR032179; Cry22Aa_Ig-like.
DR InterPro; IPR014755; Cu-Rt/internalin_Ig-like.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001119; SLH_dom.
DR PANTHER; PTHR46652; LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46652:SF3; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9 ISOFORM X1; 1.
DR Pfam; PF16403; Bact_surface_Ig-like; 1.
DR Pfam; PF02368; Big_2; 1.
DR Pfam; PF12799; LRR_4; 2.
DR Pfam; PF00395; SLH; 3.
DR SMART; SM00635; BID_2; 1.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 5.
DR SUPFAM; SSF49373; Invasin/intimin cell-adhesion fragments; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 6.
DR PROSITE; PS51272; SLH; 3.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1084
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012403707"
FT DOMAIN 887..950
FT /note="SLH"
FT /evidence="ECO:0000259|PROSITE:PS51272"
FT DOMAIN 957..1019
FT /note="SLH"
FT /evidence="ECO:0000259|PROSITE:PS51272"
FT DOMAIN 1026..1084
FT /note="SLH"
FT /evidence="ECO:0000259|PROSITE:PS51272"
SQ SEQUENCE 1084 AA; 115818 MW; 6FB2A3E197F78E85 CRC64;
MNLASLRRKT TGILLTFAMV PFTALGATAQ EAPQSASACV AGTNTYEQCL PDASLANTVA
TAANADADAV ITTDAIASLT SLNARHAGIK DLTGLDTFTN LTTVQLSNND IVSLAPLSAL
TKLTDLELYG NLIADLTPLS TLTALTKLGL GDNELTDITP LAPLTSLVTL NLSHNGITSI
DALGDMTKLE YLWASGNEIS NADVVNNLTA LKGGDLSTNG VLSAAYITSD PEEYLVMTGQ
AIKTAVTVKH GDTVTAPMPI GYDGKPVTPV GIDNNGVFDA STGQVSWKTT ADMYSGITFI
ARYESQGGGK SGDRPFSGRI SVKVVFENEA DMTTDTGVPA QPRKHEQVIT QAVATTCDGT
TTIADCFPDK ALAQVIAKQL ETDVAHVITA EELDSITEID ADNAGIVVLS GVEHLKNLKT
VHLSDNQISD LTPLRDCEHL YDVRLYNASV SDVSALANKT ELWGIGLGNN FIKDFSTMTN
VPKLGWADVY SNLIEDVSFI GQWPNCGSIW LSGNPFTDVS PLAKATQLDR LQLENNAISD
MSPFAGFSPK QYSMNDNQGI NMGDVTVDAG GEVTVSTAKG RAGGYLRPKK ISPEGGVYDA
ATGTVIWKDV SDSGVYSVKF SESDDRDYLY SGIVYRNVTV EHADKTPPDI SGVFPTYSTL
GEPYDPLFGV QAHDNVDGDV TDRITVPLNE VDINKEGTYR VRYYVEDSAH NGSWSGRRVT
VTTATISSIK VWPKWTDPGV APDMGNYAEA TWSDGNVTGE GVVWDKIDPE QYATPGNTFT
VHGKVRGRDV STTVTVRGEA PTIAVESVTI NGDGLKDGAI TLHTGDTVAL KAIVKPDDAT
KKTVSWSSSS NYIASVNAEG KVTANKVGTA TITASADGKS SSITVTIPDR FSDVPNGKAF
HDEIEWLAAN KISQGNSDGT YGYGKTLSRQ DMAIFLYRMA KLEKVEGAES FTPTEADYKR
FADVKQGSFA AKEILWLAKT GISQGSNGRF NGTAQLTRQD MAIFLYRFAK LAGSKSATDF
TPTEEDYAKF KDVKQGSFAA KEILWLASER ITLGNSDGTF GGNSKLSREA MAAFLYRIHN
HLAK
//
