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Database: UniProt
Entry: A0A2A2FBD2_9GAMM
LinkDB: A0A2A2FBD2_9GAMM
Original site: A0A2A2FBD2_9GAMM 
ID   A0A2A2FBD2_9GAMM        Unreviewed;       537 AA.
AC   A0A2A2FBD2;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   16-JAN-2019, entry version 9.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=CK501_02470 {ECO:0000313|EMBL:PAU82034.1};
OS   Halovibrio sp. YL5-2.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halovibrio.
OX   NCBI_TaxID=2032626 {ECO:0000313|EMBL:PAU82034.1, ECO:0000313|Proteomes:UP000218896};
RN   [1] {ECO:0000313|EMBL:PAU82034.1, ECO:0000313|Proteomes:UP000218896}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YL5-2 {ECO:0000313|EMBL:PAU82034.1,
RC   ECO:0000313|Proteomes:UP000218896};
RA   Dong X., Zhang G.;
RT   "Halovibrio sewagensis sp. nov., isolated from wastewater of high
RT   salinity.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PAU82034.1}.
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DR   EMBL; NSKD01000001; PAU82034.1; -; Genomic_DNA.
DR   Proteomes; UP000218896; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000218896};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218896}.
FT   DOMAIN      234    362       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      445    514       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     242    249       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   537 AA;  60056 MW;  C407717B3C966CA8 CRC64;
     MGAFTGGERR VEYRSCRGET RPKKNNARSA VVAQEIWQQC LELLQDEFPA QQFNTWLRPL
     QSRNDGGALV LLAPNRFVRD WVSQKYLDRI EEVIRDLNGA KGLQVEVKVG SAEDRQPRSS
     QPQADRGDRA VKRQSADSAG SEVGSASAEV APPVNDAELN TADERPVEDS PVAARIAGRA
     KGGGDDRRAN VEGGVQHSET FLNQQFTFGT FVEGKSNQLA RAASSQVAEN PGGSYNPLFL
     YGGVGLGKTH LMHAVGNEIV RRNPGARVAY LRSERFVADM VKALQLNAIN DFKRFYRSLD
     ALLIDDIQFF AGKERSQEEF FHTFNALLEG GQQVILTCDR FPKEIVNMEE RLKSRFGWGL
     TVMVEPPELE TRVAIIMKKA EQAQVSISNE AAFFIAQKIR SNVRELEGAL KLVIANSHFT
     GQQITPAFIR ESLKDLLALH EKQVSIDNIQ RTVAEYYKMK VADLHSKRRT RSITRPRQMA
     MALAKELTSH SLPEIGDAFG GRDHTTVLHA CKKIEELQES DANIREDYQN FLRLLTT
//
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