ID A0A2A2HB95_9EURY Unreviewed; 256 AA.
AC A0A2A2HB95;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase {ECO:0000313|EMBL:PAV06692.1};
DE EC=2.7.1.49 {ECO:0000313|EMBL:PWL08804.1};
DE EC=2.7.4.7 {ECO:0000313|EMBL:PWL08804.1};
GN Name=thiD {ECO:0000313|EMBL:PWL08804.1};
GN ORFNames=ASJ82_04485 {ECO:0000313|EMBL:PAV06692.1}, MSCUN_02960
GN {ECO:0000313|EMBL:PWL08804.1};
OS Methanosphaera cuniculi.
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanosphaera.
OX NCBI_TaxID=1077256 {ECO:0000313|EMBL:PAV06692.1, ECO:0000313|Proteomes:UP000217528};
RN [1] {ECO:0000313|EMBL:PWL08804.1, ECO:0000313|Proteomes:UP000246004}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 4103 {ECO:0000313|EMBL:PWL08804.1,
RC ECO:0000313|Proteomes:UP000246004};
RA Poehlein A., Seedorf H., Daniel R.;
RT "Genome sequence of Methanosphaera cuniculi DSM 4103.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PAV06692.1, ECO:0000313|Proteomes:UP000217528}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1R-7 {ECO:0000313|EMBL:PAV06692.1,
RC ECO:0000313|Proteomes:UP000217528};
RX PubMed=28826405; DOI=10.1186/s12864-017-4036-4;
RA Gilmore S.P., Henske J.K., Sexton J.A., Solomon K.V., Seppala S., Yoo J.I.,
RA Huyett L.M., Pressman A., Cogan J.Z., Kivenson V., Peng X., Tan Y.,
RA Valentine D.L., O'Malley M.A.;
RT "Genomic analysis of methanogenic archaea reveals a shift towards energy
RT conservation.";
RL BMC Genomics 18:639-639(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV06692.1}.
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DR EMBL; LMVN01000027; PAV06692.1; -; Genomic_DNA.
DR EMBL; LWMS01000009; PWL08804.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2HB95; -.
DR OrthoDB; 43786at2157; -.
DR Proteomes; UP000217528; Unassembled WGS sequence.
DR Proteomes; UP000246004; Unassembled WGS sequence.
DR GO; GO:0008902; F:hydroxymethylpyrimidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01169; HMPP_kinase; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR InterPro; IPR013749; PM/HMP-P_kinase-1.
DR InterPro; IPR029056; Ribokinase-like.
DR NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR Pfam; PF08543; Phos_pyr_kin; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:PAV06692.1};
KW Transferase {ECO:0000313|EMBL:PWL08804.1}.
FT DOMAIN 21..249
FT /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT /evidence="ECO:0000259|Pfam:PF08543"
SQ SEQUENCE 256 AA; 28410 MW; 45451FC237053047 CRC64;
MYIENKFKEE KPCSMTIAGL DPSAGAGLLA DLKTFQAHDI YATCVCSTLT AQNPFEVKNV
EKVDPSFIAD EIDMIMDAYP IKYIKTGVLY ANDIIKIVNK KVVEYDLSVI VDPVMISESG
CDLSGDNFAD NLKENLLKNA YLTTPNIHEA EKLTNMKIQT EDDMINSALK LNKYCNCVIT
GGHLYGNDIL CVDGEITKIK GNMIKSDNTH GTGCNYSAAI TSNLIHEKSL KQSCHNANKY
IQKAIMNGFY NTPYQF
//
