ID A0A2A2HC19_9EURY Unreviewed; 443 AA.
AC A0A2A2HC19;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:PAV07051.1};
DE SubName: Full=T-protein {ECO:0000313|EMBL:PWL07564.1};
GN Name=tyrA {ECO:0000313|EMBL:PWL07564.1};
GN ORFNames=ASJ82_02135 {ECO:0000313|EMBL:PAV07051.1}, MSCUN_15390
GN {ECO:0000313|EMBL:PWL07564.1};
OS Methanosphaera cuniculi.
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanosphaera.
OX NCBI_TaxID=1077256 {ECO:0000313|EMBL:PAV07051.1, ECO:0000313|Proteomes:UP000217528};
RN [1] {ECO:0000313|EMBL:PWL07564.1, ECO:0000313|Proteomes:UP000246004}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 4103 {ECO:0000313|EMBL:PWL07564.1,
RC ECO:0000313|Proteomes:UP000246004};
RA Poehlein A., Seedorf H., Daniel R.;
RT "Genome sequence of Methanosphaera cuniculi DSM 4103.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PAV07051.1, ECO:0000313|Proteomes:UP000217528}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1R-7 {ECO:0000313|EMBL:PAV07051.1,
RC ECO:0000313|Proteomes:UP000217528};
RX PubMed=28826405; DOI=10.1186/s12864-017-4036-4;
RA Gilmore S.P., Henske J.K., Sexton J.A., Solomon K.V., Seppala S., Yoo J.I.,
RA Huyett L.M., Pressman A., Cogan J.Z., Kivenson V., Peng X., Tan Y.,
RA Valentine D.L., O'Malley M.A.;
RT "Genomic analysis of methanogenic archaea reveals a shift towards energy
RT conservation.";
RL BMC Genomics 18:639-639(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV07051.1}.
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DR EMBL; LMVN01000023; PAV07051.1; -; Genomic_DNA.
DR EMBL; LWMS01000047; PWL07564.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2HC19; -.
DR OrthoDB; 24743at2157; -.
DR Proteomes; UP000217528; Unassembled WGS sequence.
DR Proteomes; UP000246004; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036690; Fdx_antiC-bd_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR046825; PDH_C.
DR InterPro; IPR046826; PDH_N.
DR InterPro; IPR008299; Prep_DH/arog_DH.
DR InterPro; IPR003099; Prephen_DH.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF20463; PDH_C; 1.
DR Pfam; PF02153; PDH_N; 1.
DR PIRSF; PIRSF006549; PDH_arog_dh_reg; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF54991; Anticodon-binding domain of PheRS; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 7..288
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 443 AA; 50047 MW; 55B8F0A5EEC689D1 CRC64;
MTCNENIKIS IIGGTRGLGK WIAQELKKDN FNITITSRNK DSGEKVANKL NVNYTDDNIE
AVKNADITIF SVPIEYMVDT IKQVAPHAQE GSLLVDVTSV KTETAETLTK YAPSNVNILP
THPMFGPRIT SLDGQVVILT PIDKRCDLWY EKVFHYLNKK GAKIVVSTPQ EHDKTMSVVQ
GLTHFSYISI ASTIQQLQIS VKKSREFASP VYSLMLDMIS RIVSQNPYLY YSIQKSNPKT
QYARGELIKQ MQYLSDLINN DEEEEFVKNM SSSARYLDEY EEALGRSDKA ISILTDDFKH
IKNSIGSEIG LQHQYSGNVH IGKVINVNSD NVTILDLKNN TITLKISNVT IMSDDEIYQW
KVDNLPIHNY DISVILPVSC NEEVLLDMFS KIEPIISVEL KDVYAGKQIK DGFMSYTFTY
SVFNKSDKEV VEDYMLGIGG IIR
//
