ID A0A2A2HEU9_9EURY Unreviewed; 745 AA.
AC A0A2A2HEU9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=ATP-dependent RNA helicase RhlB {ECO:0000313|EMBL:PWL08835.1};
DE EC=3.6.4.13 {ECO:0000313|EMBL:PWL08835.1};
DE SubName: Full=Hef nuclease {ECO:0000313|EMBL:PAV07959.1};
GN Name=rhlB {ECO:0000313|EMBL:PWL08835.1};
GN ORFNames=ASJ82_01590 {ECO:0000313|EMBL:PAV07959.1}, MSCUN_02740
GN {ECO:0000313|EMBL:PWL08835.1};
OS Methanosphaera cuniculi.
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanosphaera.
OX NCBI_TaxID=1077256 {ECO:0000313|EMBL:PAV07959.1, ECO:0000313|Proteomes:UP000217528};
RN [1] {ECO:0000313|EMBL:PWL08835.1, ECO:0000313|Proteomes:UP000246004}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 4103 {ECO:0000313|EMBL:PWL08835.1,
RC ECO:0000313|Proteomes:UP000246004};
RA Poehlein A., Seedorf H., Daniel R.;
RT "Genome sequence of Methanosphaera cuniculi DSM 4103.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PAV07959.1, ECO:0000313|Proteomes:UP000217528}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1R-7 {ECO:0000313|EMBL:PAV07959.1,
RC ECO:0000313|Proteomes:UP000217528};
RX PubMed=28826405; DOI=10.1186/s12864-017-4036-4;
RA Gilmore S.P., Henske J.K., Sexton J.A., Solomon K.V., Seppala S., Yoo J.I.,
RA Huyett L.M., Pressman A., Cogan J.Z., Kivenson V., Peng X., Tan Y.,
RA Valentine D.L., O'Malley M.A.;
RT "Genomic analysis of methanogenic archaea reveals a shift towards energy
RT conservation.";
RL BMC Genomics 18:639-639(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV07959.1}.
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DR EMBL; LMVN01000004; PAV07959.1; -; Genomic_DNA.
DR EMBL; LWMS01000008; PWL08835.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2HEU9; -.
DR OrthoDB; 11644at2157; -.
DR Proteomes; UP000217528; Unassembled WGS sequence.
DR Proteomes; UP000246004; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0051716; P:cellular response to stimulus; IEA:UniProt.
DR GO; GO:0006259; P:DNA metabolic process; IEA:UniProt.
DR CDD; cd12089; Hef_ID; 1.
DR CDD; cd20075; XPF_nuclease_XPF_arch; 1.
DR Gene3D; 3.40.50.10130; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 1.20.1320.20; hef helicase domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR006166; ERCC4_domain.
DR InterPro; IPR041755; Hef_ID.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR14025; FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER; 1.
DR PANTHER; PTHR14025:SF20; FANCONI ANEMIA GROUP M PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF02732; ERCC4; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF21210; RNA_helicase_helical; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00891; ERCC4; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:PWL08835.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:PWL08835.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 24..189
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 350..514
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 745 AA; 85612 MW; 093BB7D0FDAA6F97 CRC64;
MARWIEHKYI KENKIEARLY QQKIASDALI DNTMVIAPTA IGKTVIAALV SAEVLNHNPD
SKILFLAPSK PLTLQHEKSF NEFIKAKTTS LTGNNKPSER RKLWHENQII CATPQTIESD
IISQEYDLSD VALIIFDECH HAVGSYSYVY LAQKYIQTAK NKQVLALTAS PGWEEDKIKE
VSRNLYIKNV EIKTEDDVDV APYFNPIEVK WIKLKLTPEL EEIRTLFKET LKIRLRNLKK
IGVIDSVAKP SKKDILMKQR MVQRKIASNA NPPKECFKAI SLLTEVINIT HTLELLETQT
IQTLNKYLNK LEKKKTKAAR SLKNDYKFNK AVLLARRYEN EGIDHPKLER IKTLIEDILR
EDPTNKIIVF SQFRDTTKTI YDNLKADKIK ALRFYGQASR EKDKGLSQKK QIETIDKFKN
EDYNVLISTS VAEEGIDIPS VDYVILYEPV PSEIRMIQRR GRTGRKSKGE MYILMTKSTV
DEAYFWSSQR KEKAMKQNIH KKYDTQKFTL DNYIADDKDV TSYNPNTQDD IQTTVYVDYR
EKNSNIMREL DKIGCKIVVK TMAIGDYQLS DDVIIERKTV DDFAKSITDK RLYTQAKELA
SNCNKPLMII EGGDIYNTFL HPNAIRGAMS SIAIDFKIPI IQTQNETDTA MMIKTIAQRE
QKDKEDKKPV SIRTQTKPLT LKEQQLFITE SLPGIGPVSA KKLLTHFGCV KNLINATKNE
LKEVEGIGNK TSENIIDVTT RKYQE
//
