ID   A0A2A2IEE7_9BACI        Unreviewed;       194 AA.
AC   A0A2A2IEE7;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   RecName: Full=Adapter protein MecA {ECO:0000256|HAMAP-Rule:MF_01124};
GN   Name=mecA {ECO:0000256|HAMAP-Rule:MF_01124};
GN   ORFNames=CIL05_11690 {ECO:0000313|EMBL:PAV29520.1};
OS   Virgibacillus profundi.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Virgibacillus.
OX   NCBI_TaxID=2024555 {ECO:0000313|EMBL:PAV29520.1, ECO:0000313|Proteomes:UP000218887};
RN   [1] {ECO:0000313|EMBL:PAV29520.1, ECO:0000313|Proteomes:UP000218887}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IO3-P3-H5 {ECO:0000313|EMBL:PAV29520.1,
RC   ECO:0000313|Proteomes:UP000218887};
RA   Xu B., Hu B., Wang J., Zhu Y., Huang L., Du W., Huang Y.;
RT   "Virgibacillus indicus sp. nov. and Virgibacillus profoundi sp. nov, two
RT   moderately halophilic bacteria isolated from marine sediment by using the
RT   Microfluidic Streak Plate.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. Acts negatively in the development of competence by
CC       binding ComK and recruiting it to the ClpCP protease. When
CC       overexpressed, inhibits sporulation. Also involved in Spx degradation
CC       by ClpC. {ECO:0000256|HAMAP-Rule:MF_01124}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738, ECO:0000256|HAMAP-
CC       Rule:MF_01124}.
CC   -!- DOMAIN: The N-terminal domain has binding sites for ComK and probably
CC       for unfolded/aggregated proteins; the C-terminal domain interacts with
CC       ClpC. {ECO:0000256|HAMAP-Rule:MF_01124}.
CC   -!- SIMILARITY: Belongs to the MecA family. {ECO:0000256|ARBA:ARBA00005397,
CC       ECO:0000256|HAMAP-Rule:MF_01124}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAV29520.1}.
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DR   EMBL; NPOA01000007; PAV29520.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A2IEE7; -.
DR   OrthoDB; 2085234at2; -.
DR   Proteomes; UP000218887; Unassembled WGS sequence.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR   GO; GO:0045808; P:negative regulation of establishment of competence for transformation; IEA:UniProtKB-UniRule.
DR   GO; GO:0042174; P:negative regulation of sporulation resulting in formation of a cellular spore; IEA:UniProtKB-UniRule.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.1950; -; 1.
DR   HAMAP; MF_01124; MecA; 1.
DR   InterPro; IPR038471; MecA_C_sf.
DR   InterPro; IPR008681; Neg-reg_MecA.
DR   PANTHER; PTHR39161; ADAPTER PROTEIN MECA; 1.
DR   PANTHER; PTHR39161:SF2; ADAPTER PROTEIN MECA 2; 1.
DR   Pfam; PF05389; MecA; 2.
DR   PIRSF; PIRSF029008; MecA; 1.
PE   3: Inferred from homology;
KW   Competence {ECO:0000256|HAMAP-Rule:MF_01124};
KW   Sporulation {ECO:0000256|HAMAP-Rule:MF_01124}.
SQ   SEQUENCE   194 AA;  22796 MW;  82D14F9E83D474CB CRC64;
     MRIERVSDDQ FTIFLTFDDL IERGFTKEDL WHDASSVQNL FSDMMYEAST ELGFELDGML
     LVQVHLMQAQ GMHVIVTQKY ENINWDEDFI EMKVTLDESK ELIFSFEEFE DVIRVASYLT
     ALSIDGGQVY HMDGRYYMLL NDDDLVNKNK ENIIAVMSEY SYPSIITSYR LKEYGKVIFM
     GNAVQQIIHN FYYS
//