ID A0A2A2IVD4_9PSED Unreviewed; 805 AA.
AC A0A2A2IVD4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122};
DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122};
GN ORFNames=CK486_10830 {ECO:0000313|EMBL:PAV48190.1};
OS Pseudomonas sp. HAR-UPW-AIA-41.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=1985301 {ECO:0000313|EMBL:PAV48190.1, ECO:0000313|Proteomes:UP000243299};
RN [1] {ECO:0000313|Proteomes:UP000243299}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HAR-UPW-AIA-41 {ECO:0000313|Proteomes:UP000243299};
RA Kumari P., Krishnamurthi S.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122};
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV48190.1}.
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DR EMBL; NSLB01000004; PAV48190.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2IVD4; -.
DR OrthoDB; 9758568at2; -.
DR Proteomes; UP000243299; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041699; AAA_32.
DR InterPro; IPR046844; Lon-like_helical.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR046843; LonB_AAA-LID.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR PANTHER; PTHR10046:SF49; LON PROTEASE HOMOLOG-RELATED; 1.
DR Pfam; PF13654; AAA_32; 1.
DR Pfam; PF05362; Lon_C; 1.
DR Pfam; PF20436; LonB_AAA-LID; 1.
DR Pfam; PF20437; LonC_helical; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000243299};
KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01122}.
FT DOMAIN 563..758
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT COILED 206..233
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 653
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 696
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 805 AA; 88413 MW; 467B9C89FDF3AFA9 CRC64;
MAATAVAALK LQPEELTRPY SPDQFNFAST DELEPFRGVL GQERAVEALQ FGVAMPRPGY
NVYVMGEPGT GRFSFVKRYL QAEAKRLATP ADWVYVNHFD DPREPRALQL PPGEGAQLIA
DINQLIDNLL STFPAAFEHP TFQQKKNAID RAFNQRYDKA LDIIEKASLE KDVALYRDSA
NVAFTPMKDG KALDEAEFAQ LPEAERERFH RDISALEEQL NEELASLPQW KRESSNQLRQ
LNEETITQAL LPLLAPLSAK YAENASVVAY LQAMQVNLLK TVVDQMVEDN RSDAQRRRAL
EEDYSPSLVV GHHAQGGAPV VFESHPTYDN LFGRIEYNTD QGALYTSYRQ LRPGALHRAN
GGYLIVEADK LLSEPFVWDA LKRALHSRQL KMESPLGDLG RLATVTLTPQ VLPLQLKVVI
VGSRELYYTL QDLDPDFQEM FRVLVDFDEE IALSDESLEQ FAQLLKTRTS EEGMAPLTGA
AVARLATYSA RLAEHQGRLS ARIGDLFQLV SEADFIRHLA GDALTDVGHI ERALKAKADR
TGRVSARILD DMLAGIILID TRGAAVGKCN GLTVLEVGDS AFGVPARISA TVYPGGSGIV
DIEREVNLGQ PIHSKGVMIL TGYLGSRYAQ EFPLEISASI ALEQSYGYVD GDSASLGEVC
TLISALSRTP LKQCFAITGS INQFGEVQAV GGVNEKIEGF FRLCEARGLT GEQGVIIPRA
NVTNLMLDER VLQAVRGGQF HVYAVSQVDE ALSLLVGTDA GTPDEQGVFP EGSVNAQVVA
RLREIAELGM EDDDKGKDKD KSDAS
//
