ID A0A2A2J2J6_9BILA Unreviewed; 918 AA.
AC A0A2A2J2J6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 13-SEP-2023, entry version 18.
DE RecName: Full=Protein vav {ECO:0008006|Google:ProtNLM};
GN ORFNames=WR25_24935 {ECO:0000313|EMBL:PAV55837.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV55837.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV55837.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV55837.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV55837.1}.
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DR EMBL; LIAE01010745; PAV55837.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2J2J6; -.
DR STRING; 2018661.A0A2A2J2J6; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd20810; C1_VAV; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00174; SH3; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR PANTHER; PTHR45818:SF3; PROTEIN VAV; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 6..125
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 217..410
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 577..629
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 652..714
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 762..852
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 857..918
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 918 AA; 106173 MW; 033A85BD4188648E CRC64;
MTSDSEELWR SCVRWLLDLG VIDRSHLPAN ELKVKQFASI LRDGVLLCKT AEMLCSGCIP
TPPEIQKNTQ LLSQFISSKN IVLFLNACRN TFNIPEEFLF EPLDLYHYND FVKVLQTLSI
LSHTNYSKCR DIQPFPEKVL NETALPCCPL RANVVEEEIY RNLNEEVEDV EGVDQAIYGD
INKKEAETHI IYEHLVNRRD SQRKERDEWY KFVPTTKREY SIKELLDTET NYVDKALQMI
MSRLYSPLRL HLKEDDHKAI FINISELYEL HQKFHNDLRQ SILRTLGLNE SSNGRPISMS
RNIGEIFLMY KDKFVAYGPY CTKLDESRER ILQLEKSDSN AKARILECTS ANDNQFKLQD
LLCLPMQRIL KYSLLLQELL KHTPIESPDR KSLDLAKEAM DDINSYINEM KRDHEMMQFI
DEVEKSISDL TMPTNVKLSD YGRLNLDGEV KLLETYSSHS GKMKQRYVFI FDKVIIICQA
NRNNTYKYKN AHILCEFSIS QDSPIPVGGT ITKKLLAGNH QHILHFHRAK APNEKDRDPV
TQIAMAFKSE PQKQRWMQQF ELSKSNVNPI EAVRMSGHNL HYMSFSPHEP LHCHVCHKLF
KGLFFQGYEC LNCHKLLHRQ CLALEKCNAR KSILSNGHSF NRPKSSPLLN FSKGDMVIAL
RTVTPSTIQH LPFDKDDVIL VEEPLADSTF IGALSTNSSR TGIVSMDCVK KLRQNSICNP
SSNIERKEST VLPRRPNRES GILSNQQSFQ EYVNTEIGSQ SWFMGQMKRS DAESKLKGTP
NGTFLVRYSP NRGTYAISIS YQDEVKHMAI EQNDGKQFYL DDGYNFNSIV ELINYYRVHN
LIEIFNTLNT TLKSAYRDCK IYKVIHDFEG SEAKFLTIRK GDLVTLVDTI GEERGWWKIM
LNNKVGFAPL SYMEPLED
//
