ID A0A2A2J9P7_9BILA Unreviewed; 934 AA.
AC A0A2A2J9P7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=WR25_14719 {ECO:0000313|EMBL:PAV58329.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV58329.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV58329.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV58329.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV58329.1}.
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DR EMBL; LIAE01010588; PAV58329.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2J9P7; -.
DR STRING; 2018661.A0A2A2J9P7; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700:SF3; UBIQUITIN-PROTEIN LIGASE E3B; 1.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 561..934
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 902
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 934 AA; 105656 MW; 18A8D5D08C035687 CRC64;
MDGTLKCLEK NAKLREEAEL DHRRKALAAK LEPVVLGWKT RRKYNFQTRL GSRVYEVQHI
LNGLLSKLNS TLYEEDNYRK LANSLFKACN DQKPLISVEA LSAQFSIVLK LIREEDRLLN
MFIVHVCTAP ALIMHINQST KDAFTSSKIY ERILARLRKD ESLIDDLNAN LILYLLGNII
HMSYIEPQTT REHVLDFTWA VAALLGDCTQ YVVKFSRKNH HHWHPIFGDS TIPIDRQTEG
ALKNVQTQLR LLWSAKIISC LFDKAFEGLN LNSDSGRTKK SSEPTKELSK TMEKLWKKLS
KGIDGLSSSS AEEFKASEPT LTSVVAALFN TALITMPHTR SELNSALCRD DAILRQLWRY
ITSLPSIKGQ SSSISSAVSF YSRCLPSVTH YSAPLQLFCD SAASLISILD EEELFQKGVP
FSIGDLIDMC KFCNLFCFKA IWTGLIDDAN INDNNLFTSV HNLCMALFAR DTRRPFSADS
KFWIPTEPKS SAIVAEFEKR TPKGLILMNR LSHVVPLKDR MVLFRKQVSA EKASLDGHPT
LITVMRSRLL DDGYRQLAGL TTNALKATIR VKFINEQGLD EAGIDQDGVF KEFLELIVKK
VFDPELNLFQ STSSGVLYPS LTSSLHEDHL QLFQFVGRML GKAVYEGIVI DIQLAPVLLA
AVLGGRRLCA FDELSQLDPE LYRNLSFVKK YQGDVATDLS LTFSIDEDFL GKINTVDLIP
GGRTIPVTNE NRRDFYLVFK IIIDYVHRMA HHRVFVQTRE QCRAFVQGVQ SVLSASQLSI
FSPHELQCLI SGQSSDIDLA DLKKHVQYYG GFHGGHRLIK WLWDIVENDF SAEERKLFLK
FVTSCSRPPL LGFSYLEPPF SIRCVEVSDD QDQGDTLASV VRGFLALKKE KSALRLPTAS
TCFNLLKLPN YNKRSILLQK LRYAIRAEAG FELS
//