ID A0A2A2JAH3_9BILA Unreviewed; 1532 AA.
AC A0A2A2JAH3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Rap guanine nucleotide exchange factor 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=WR25_10055 {ECO:0000313|EMBL:PAV58673.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV58673.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV58673.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV58673.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV58673.1}.
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DR EMBL; LIAE01010566; PAV58673.1; -; Genomic_DNA.
DR STRING; 2018661.A0A2A2JAH3; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF249; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231}.
FT DOMAIN 152..199
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 455..520
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 585..699
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 704..775
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 889..976
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1001..1240
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 285..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 853..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1337..1475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1487..1532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..311
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1337..1351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1358..1451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1494..1532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1532 AA; 171120 MW; 85E55E2A51133AE5 CRC64;
MGELCRKPSA VYIDCIEYVP PLLLYALLAR KMSGRLSADP RMERLSDMSA IRLEYIRFGA
KFSFLLVNSR AFDQSLNGEK RSEEKKEGRG RSPLLLLCAE VQAVHCALCI VHCGGMDPIN
DARFYESLIK APHLRTGEDI RNIYEQLRQM EMFANLYNGP LKAICASARY ERHPAHYILF
REGQLASSWY ILVSGSVFID NHIYLPFASF GKRNGLNYRR SHDCMLLQES EMIVIDYPDA
TQVSSSPPVV VTSASVGGYS PHSSNVPSPA PSTRLVRKSL HTMQPAEMLP PPVPPRPRGS
APPPPRGLPR SYPVEFPVDV PSTSTYPLEP NHKSQVYLNG SIGDEDTLVR VKHRREKSNS
VGGAATIAIT PPSIMNGPIR RLRVRSTASS TTTEGEEGAS NEAGDSDEDD DGSVPSHESY
VDLKDCVREA LEKEPSERNS EDISVLMEFM SHMSSFHRLP MSIKRELCLK MVFAVVNDAG
TVVMQHNEKL DSWTVIVNGC VEVVKPNGDR VEYKLGDSFG AEPISTVQYH EGEMRTLVDD
CEFVLVEHRD FCSIMSQVDE HIVREEDDSK NTILEKEKRT VGTQSGLILI KGKPDRLIQH
LVDERDHSVD PNYVDDFLLT YRVFIHDPTV IFEKLMLWFA DSVYRDKVAR IVLLWVNNHY
NDFETNKEML RLLERFEGAL ERDGMHSQQS LLNIACSVKA KPRLITHTRA NKEEPLQFSL
VGGKDLQTGI FISEVKADSQ AEKVGIKKCD ELLEVNQQNV KYISVQRAQE LLMGSLSLTL
LLKSNILGFK ELMSRLNEKD GGSKNGAQKN IPHGKNSLPL VVPVKTPRTI KGPAKSNMMD
KLLTILKANK DEDLTDESRH STSELRPSRS NPDIASISQY YGPVKSDSPE HVLKIFRSDQ
TYKYFPVYKE TTAQNVVQLA LQEFGMTNEG SLEWSLCEVT VTPDGVIKQR RLPPILENLA
ERIALNSRYY LKNNNRSDPL VPDELAPELL KEAQTQLLLL NAQVVAAQLT LQSFAIFSAI
EPTEYIDSLF QLESKYGLPK LEEFEKQFNR EMWWVATEIC LERSVQRRAK LIKKFIKIAR
HCRDLRNFNS MFAIISGLEK PAIRRLHSSW ERVSGKYMRM LEDIQQLVDP SRNMSKYRQH
LAEVSQEPPV VPIYPVIRKD LTFAHEGNPT YTDRLVNFEK LRLIAKSVRA VTKLSSAPYE
IGSMAERSGG SITDALLHMN TFEGSNVATM RKGTKANQPR KKIYEQALMV RKVKAYLEGH
QVIDSEMELD RLSYDIDPQV QTANRGAIRR PPSPTLSTHS SQSAGSSEQR KFPGAKFGVE
SPQAMQKMLT LVQNTTRLKG SSPSASPGSA SRGHKNVPRV NARQSSVPHI QRIPSVKTEP
VPLSSETSSV TSYYSNGSSG QSSCPSNSSG SRPRSGSELP IPFSTSISIV PPSDSSRNHG
LSTSLHAPSS NRLSPRLPPR VPSSSPSPSS ASISSSISSA LRGVVLGHRP VPSYSPQPKS
SSNSNSNSSA HRNMATIKES TQILPAEQIS RV
//
