ID A0A2A2JC60_9BILA Unreviewed; 2005 AA.
AC A0A2A2JC60;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=EGF-like domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=WR25_24165 {ECO:0000313|EMBL:PAV59336.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV59336.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV59336.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV59336.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV59336.1}.
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DR EMBL; LIAE01010530; PAV59336.1; -; Genomic_DNA.
DR STRING; 2018661.A0A2A2JC60; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 1.
DR Gene3D; 2.10.25.10; Laminin; 10.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 6.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR042635; MEGF10/SREC1/2-like.
DR PANTHER; PTHR24043:SF8; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24043; SCAVENGER RECEPTOR CLASS F; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 29.
DR SMART; SM00179; EGF_CA; 9.
DR SMART; SM00180; EGF_Lam; 16.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS00022; EGF_1; 10.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 20..102
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 101..139
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 182..222
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 306..346
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 390..430
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1523..1558
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT COILED 1595..1759
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1792..1932
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 110..127
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 129..138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1548..1557
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2005 AA; 223085 MW; 1AFDB061BF29104C CRC64;
MARTELNESE KRTVKELQKK PNVCSHEERE IAIVKKPCVQ AYTKYVRTRK PGCNGQARSC
FVREPKTVYY HTYKSENRTR RHLVAECCPG WIQIPGQEGC QRANCTADLC HNGGTCLPIR
NGTEQICDCL SGFTGAKCQY DVNECVVDNG GCAHDCVNTI GTFYCRCWTG FVLSEDGKNC
NDIDECEASN GGCSHRCINS PGGYRCDCPS NMQLASNGRK CVDASSCAAE NGGCAHICEE
KDGKFYRCRC NAGYKSGHDK RSCIAIDPCL ENKGGCQHHC VSENGKAHCQ CYPGFRLSYD
RRTCVDVDEC AQNKHECQHD CVNVHGSFRC QCRPGFTLAE DGRSCEEKVS GCQVSNGGCE
QECFDQPDGG HICGCRDGFR LDANGRDCID IDECIEGTHS CEQVCHNIPG SFECKCREGY
RLSQDKRACE DVDECQSGYA NCQQLCFNKI GGFVCDCREG YLLGPDERTC HDINECLVNN
GGCSQLCRNE EEGRRCECFG GYVLAEDRIT CIDVISNYKQ LDDSSFASRN TLDLDEDMPS
PISVQIENVN VQESQPSSVY RQLKFRRMKA PQEEDGCPEG TYGIGCNQIC RCKRCDINGN
CKCPPNEECE DGPCPIGYFG PKCDLPCRLN CPGDGKCDFE FGDCLCDAGR FGENCDQTCP
PFKFGKNCRL DCKCDRNNCD GCDAKSGRLH CKSGFYGPHC KRRCPIGTWG IDCSRKCDCQ
NGNQYCDPVT GECNRRCPPG YLGVLCDQVC KSGFYGNDCA EKCQQQPCHH VTGNPFCSKP
GVAGENCDQP CDPNHYGPNC MYECQCKFNS TCNPRDGSCI CSPGYYSSDC GTACPHGRYG
SDCQQLCNCQ NGGLCNPIDG SCDCREGWTS ADCSVRCPKN TYGKDCSKKC NCELGCDAMG
ECLCSAGLRG AKCDEPCEQG KFGPGCLGKC LCQHGKCDSI TGACECEAGW RGKYCGRPCS
DGTFGEKCRG ICDCNTNNDT TMYNPFVSRC HPITGECLCS EGFMGPDCKL PCPPGRFGKG
CKNVCKCAHS ESCDPISGFC DCPNGFMGRN CDQPCPKSTY GPGCLKHCIC MNNGTCDANG
KCSCVGFTGP ACEFLCPFGY YGPDCKLQCD CLNAAGCNRT TGKCECLPGW IGDRCENRCN
AQTWGQNCEE VCQCENGADC DPISGHCSCQ PGWRGRKCHK PCLKGYYGKY CSQVCKCPTG
KACDHISGRC VCPKGYTGHL CMELCPEGTW GENCENVCKG GANSTCDPIS GKVYCNPGFR
TDNSGSTDCH QGCPANKFGI NCDSTCDCEN NAKCDPMTGA CKCRSGFIGS RCEIPCAANR
YGSECEKMSV CENGGAPDGI SCNQPCPESR WGIGCKEKCM CANGGKCDSQ TGECTCAPGW
MGPSCTESCS LIAKYGANCT LDCECQGDAR CDPISGCCDC PAGKYGNRCQ FDCPDNWFGW
YCSQPCTCQN DAACDKATGE CLCKPGFQGE KCELRCQNGT FGVQCRQKCD CGEFPCDNVH
GTCICPVGLQ GPRCDEKCRN GRFGPNCDLI AQCFNGARSD HRTGTCFCSP GFYGPNCLFE
IKETSNLQKE RALVVRTQQN YSELKRIFID IEAENKSLKS KLGELDSDME EYKRMKEECE
QIEARRKQLI VEMEKDRIQR EIDAEQLRTE VLEHNRTLYQ SELEHCKKQI DDLKAERTKL
EISIQNLNEE LETVREERNR KEKEWKATVV GLKKDFEAQI EMVIEDVQRS EDQKKSMDME
KYEARIVHLE ESLLQKSEEK LNLVDEYSKK CTELDGRLHE EKKLRIEQEL KCNRLEGEVE
SSNARVKICE QQIETLHKQL NDKNLEIVAL MRETNNEGRI FKENLREEEE KWSERMKDFE
KIIDVLNKKI NLQNDQLEEA KTSQTDLLKV NEELKLYQRL LEDEKDLHQR SVQKNEERIE
LLKHKQKILE DQIVVLKKSL ESNPETSAAV NRLQEIVDRK DVEINMQRSK TRQIIEEFTT
KLDILEDRQM KMKSKIQERI LTSRI
//
