ID A0A2A2JFD1_9BILA Unreviewed; 129 AA.
AC A0A2A2JFD1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=N-terminal E2 ubiquitin-conjugating enzyme {ECO:0000256|ARBA:ARBA00042168};
DE EC=2.3.2.23 {ECO:0000256|ARBA:ARBA00012486};
DE EC=2.3.2.25 {ECO:0000256|ARBA:ARBA00039075};
GN ORFNames=WR25_07831 {ECO:0000313|EMBL:PAV60357.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV60357.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV60357.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV60357.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine +
CC [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-
CC activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-
CC conjugating enzyme]-L-cysteine.; EC=2.3.2.23;
CC Evidence={ECO:0000256|ARBA:ARBA00000485};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine +
CC [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating
CC enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].;
CC EC=2.3.2.25; Evidence={ECO:0000256|ARBA:ARBA00035805};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV60357.1}.
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DR EMBL; LIAE01010472; PAV60357.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2JFD1; -.
DR STRING; 2018661.A0A2A2JFD1; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR CDD; cd00195; UBCc; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR000608; UBQ-conjugat_E2.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR PANTHER; PTHR24067; UBIQUITIN-CONJUGATING ENZYME E2; 1.
DR PANTHER; PTHR24067:SF373; UBIQUITIN-CONJUGATING ENZYME E2 W; 1.
DR Pfam; PF00179; UQ_con; 1.
DR SMART; SM00212; UBCc; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS50127; UBC_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000218231}.
FT DOMAIN 3..129
FT /note="UBC core"
FT /evidence="ECO:0000259|PROSITE:PS50127"
SQ SEQUENCE 129 AA; 14495 MW; DE474ED98FE7EA3B CRC64;
MDSCSRRLMK ELQQLSTEPP TGIICSKDIA SDDLKQWRVE VVGAPGTLYE GERFTLQFRF
SPQYPFSSPE VMFVGQNIPA HPHVYSNGHI CLSILADDWT PALSVQSVCL SIISMLSSAK
EKVRTNNYR
//
