ID A0A2A2JI64_9BILA Unreviewed; 1110 AA.
AC A0A2A2JI64;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN ORFNames=WR25_18185 {ECO:0000313|EMBL:PAV61334.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV61334.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV61334.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV61334.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC subfamily. {ECO:0000256|ARBA:ARBA00006279}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV61334.1}.
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DR EMBL; LIAE01010418; PAV61334.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2JI64; -.
DR STRING; 2018661.A0A2A2JI64; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 3.
DR InterPro; IPR009716; Ferroportin-1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11662:SF405; MFS DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11662; SOLUTE CARRIER FAMILY 17; 1.
DR Pfam; PF06963; FPN1; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 55..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 679..700
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 707..726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 732..755
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 899..916
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 937..957
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 963..986
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 998..1021
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1033..1055
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 597..1058
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1071..1110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1073..1101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1110 AA; 122528 MW; F5AC2583319FBE26 CRC64;
MKQEDRGWSI CVALCMQLFG GMRLVSIEQL LEGVGQMIVS GYLGKAFDGM SRKSAILLAV
PLNNLSIVAA ASLFIACINS QPGSWYFIVL LILGMGLCAV NRLFLNAEKF IVGRDWVVVL
GKDDSALANL NATLTALDQF TNVIMPLVTG ILFTWLGLQS MCVIFGSAAL ISFVLKTFFL
HYLYNHEDEL RKDKVRPVRS ESTAKAEDLN GSQKSNLCST LASVFSTYYR QTVFAAALGM
AFLFMTVLGF DGLAIGYGES TGLPVSYIGL LRSFGSAMGI AGAMSYAFFE KRVGVRKTGL
IGLIWQQLFM ICAAVSIWLP GTPFHPSQYF HNTSFHDWWN ELRHTFDGGN LTYVPGHVDW
KHFTIDGVSM CSIAVFLISI AAGRYGLWMI DLSITHIMQT GVPEHQRNTV FGMHNALCQT
FSSLKDIMVI VLPDPLTFGI CILISYAVVS MGHLCYIYYL LKKQKEVVYY SYMDYRFIDE
KEVWQTRVNN WNQGVRREEA GIQRPTALFR PSESWKQSEV VSRLIRNKCL KSTFARPDRL
IFYKGMVLSE KHGSCSLAVE EDTDNLEPIL QDEFEELQYP GLFNCRSIRL WICILLIMAL
FSVGSMKNSL GMAILCMVNS TEPVAKYTSY GLVIENKCKR SAYLRPNDAA FGGKLTNSSK
SVSAIGQGTL NWSKAQQSLI FSATFYGSIL TTSFSGYLAD LVGAKRILLL AVFNIVVCSL
VSPTLAKYSY SAFFAARLMM GFGEGMIFPC VGNLAGRWFP PNEKSTAAAL ATSGNQLASA
LSSVVSAFLC TSSQGWPLIF YVFGAIGLCW CVIWCLIASD EPSQSNRISK AEVIYLTKNC
GAGKKKDRPA VPWMAIMTSK PFLAALFCQF TNNTQGSIMQ SFLPMYLNEQ LNLSLKMNGF
YTMIPFIVQL IAKNIFGILS DTLKSKGIFS HTTSAKIFQS LGSHGTSTSV ALLILVTNCE
SQAATLFILI AYGICFSATI CGFYTSVLSI APMYSGTLTS LSMVAGTLGN IVGPLLLSLL
VNFEELNENR WTILFTWCIV SNAIAGTVFL FYGSVEKKHE ALLPRKSMQC EGMRNGRNGQ
LATSKKKQLS RAEGQGRKIS KSTNSSREEA
//
