ID A0A2A2JP58_9BILA Unreviewed; 700 AA.
AC A0A2A2JP58;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=DNA mismatch repair protein S5 domain-containing protein {ECO:0000259|SMART:SM01340};
GN ORFNames=WR25_08396 {ECO:0000313|EMBL:PAV63431.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV63431.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV63431.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV63431.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV63431.1}.
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DR EMBL; LIAE01010306; PAV63431.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2JP58; -.
DR STRING; 2018661.A0A2A2JP58; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231}.
FT DOMAIN 214..330
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 371..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 78531 MW; 988FCAD249C2C015 CRC64;
MARIQKLPSD VVNRMAAGEV VVRPCNAIKE LLENSLDAGS KSISVSFYSE RDDITIQVQD
DGKGIAKDDM EIVCERFTTS KLAKFEDLQN MQTFGFRGEA LASLSLVSKM TIVTKTADQP
LAYQANYQDC KLIGQIKASA GKNGTIITAK ELFYNCPSRK KAFIGTDRFK DEVSRVMEMI
TKYAIQRPDV TFAFRTTSSS SFRTSATGDS KAVISSLLGK QFADNLIEIS CESNILRYKI
SGYISKPISA ATSRGIMDKK TKQRFFSLFV NGRSVECPKL KHAIDSSYSS RDIDPGRVDV
NVHPTKQSVI FIGMDDVVDE LQYKVLEILN ECMEDENVSF NSSQPSTSNI QKASDLSASQ
ILKQPTQLFM IPPVKKEKSK DRNSTGGNKF QQPSASPKNA AYFQNRTDSQ ERRLEQFFRI
GDSAPLNDEN KDNNGVNLVE FTASNDDVES TQFTPNSSSI RTFRLKPLDF LKAKVENEIS
PTLIGFFKNH IFVGFISVGQ CLFQFGTALY LISISEILEP FFYQISLSNF GNFVSYRIGE
PGSIRIDALL KATGDDMWES TESINNAEKL LSDNAEMLNN YFSIDEISLV SIPCIMNGLQ
PQLERLPNFM SALLYANYED QTSCFHEILM AIANFYVPKE EFCNGDKLSG LNSVNWKPML
RDKVLPYLKN RFKPPAILAD KKIINPLVDA HDLYKVFERC
//
