ID A0A2A2JPS0_9BILA Unreviewed; 1123 AA.
AC A0A2A2JPS0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein {ECO:0000256|ARBA:ARBA00019541};
GN ORFNames=WR25_07780 {ECO:0000313|EMBL:PAV63660.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV63660.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV63660.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV63660.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004557}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WD repeat SCAP family.
CC {ECO:0000256|ARBA:ARBA00007410}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV63660.1}.
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DR EMBL; LIAE01010298; PAV63660.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2JPS0; -.
DR STRING; 2018661.A0A2A2JPS0; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR030225; SCAP.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46378; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR46378:SF1; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50156; SSD; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 35..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 274..421
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REPEAT 682..723
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 873..914
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1093..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1123 AA; 128016 MW; 8FF02BD7E6C09791 CRC64;
MSIPLERVRQ KAPALKDRIA QAYHDYGRLC SAHPIACLTF SILTILVLSY PAVVRFKLPV
SSPIDVYWNY ASEEGKSNFN DGLPDWKNEP AAFYLQQVIL RAQVDPWVST NLTSEQSVRG
PLSRSFLIRD ILLRIRQVND ACLHSQHTGI PLLPSAGCLL IGPVQFWQSK LQRFKEDPDI
LSTIFAPECH PSMCIRDILL GVPTGMTGVK AKYQTNRRRS IDFSTTLFFV NYSPILRESM
LAELGKHFEI LKSPEADEII NVHVFYRPRK YFWDYFPLVA SYIVFMVYLY YSARKFEMVS
SQWGLALAAM ITVIATLTMA TGISTYFDMA PTLWGAEVYP YVALVSVVYT PPTLDVSSRI
AHGLSQEGFT LCKYFVLELI FLGLGYLTRI SEIQEFCRFA FLGLVVDFYM QLFFYAPCLT
FDLQRLGVRE KQRFAEMLFP TEIPRLKSFA PVSCPARRFF PALFAMKREM KRRLSDSQLK
KNDDELQSPL AQNNGLRRRR SISVSKSDYW EADESSARSS QTESSNRLKL LYFVTRTRIF
QRTIMALFTL WVIWLAFFVH SRQMTGTGDS FAASHRLLET APLQWGEWQR RTFKWWPALF
NEYNISLAGR YITFLPPIVL STNISPEDEL LKRSTTTTKK FSTQEDETPT LLRRFGEANI
EERTQEITYR LGYLDFILPI VFASHRFPIE GVRIADEGRK IISCCHEGRV LVWNSETGEV
IVRLNRMRAP VDEAKEIPKP PNVWALCASD DLVYLGCSDG SLEIACLIRN KLIGIFAQSQ
IGVSHIEICS NIIIAARLDG QLDFIRVTYS TEGPRRVSSM RLVKSVSAHH LPLRKMDVYH
PEDEEDAALI ATASMDHTVK LFNISTGSLC SVLLAHSSPV NSLCIDPSTQ TLYSSCEDGI
VCTWNMKKGE LVRSVDIGLA GPVRLTVTDE KLIGLCADGQ LCIWNKSNGH LDTRLKQQQF
ERTTMAMDSG GLCALEGDVL ACAQGRTLSF WNLQHKAIIR QIDIGSSIDR LLRVDCRRVI
CQCSNTIFPS LTEVIQLAAL LIFDDSISFS LTIFYHVISE YLRPFRNEAN GRYAGRTSDS
NWEMRIAHRK NHERNEKKVD DLWRSPRNTK KQRKSPDSNF ATT
//
