ID A0A2A2JQB6_9BILA Unreviewed; 568 AA.
AC A0A2A2JQB6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Hint domain-containing protein {ECO:0000259|SMART:SM00306};
GN ORFNames=WR25_03273 {ECO:0000313|EMBL:PAV63898.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV63898.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV63898.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV63898.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV63898.1}.
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DR EMBL; LIAE01010291; PAV63898.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2JQB6; -.
DR STRING; 2018661.A0A2A2JQB6; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0007267; P:cell-cell signaling; IEA:InterPro.
DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR GO; GO:0016540; P:protein autoprocessing; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00081; Hint; 1.
DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1.
DR InterPro; IPR001657; Hedgehog.
DR InterPro; IPR001767; Hedgehog_Hint.
DR InterPro; IPR003587; Hint_dom_N.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR006141; Intein_N.
DR PANTHER; PTHR46706; PROTEIN QUA-1-RELATED; 1.
DR PANTHER; PTHR46706:SF12; PROTEIN QUA-1-RELATED; 1.
DR Pfam; PF01079; Hint; 1.
DR PRINTS; PR00632; SONICHHOG.
DR SMART; SM00306; HintN; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR PROSITE; PS50817; INTEIN_N_TER; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..568
FT /note="Hint domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012968606"
FT DOMAIN 360..468
FT /note="Hint"
FT /evidence="ECO:0000259|SMART:SM00306"
FT REGION 243..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..273
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 61094 MW; 97FD3E081691C98F CRC64;
MQLSHCVGVL LLSVHYGLAS FCGDSAVPFS FEALPDGQPV LGCSRPACFG WSAAGQPFSD
KFSFYTVNGH PDGFFQPLYH AISPFQPGDG SHYPEQFARC DDTYRSNSCD DSTQWVGGIA
PVLNASGYPL VLQCCTYDPL RYSTDRGIAT IHTGEIFAGG EVTKNNQTYA FDYISNVERK
VDESGRIFYE ISVKRLPCSG DARISPIPED MASAIRDLNS QRLGRSGPAL GAPNLNNVNA
LPLPGGGQYA SGGPQPLPFP QPNSYSQPAP APAPLPPVNS YAGAAIPQYG TSLSGGNYAQ
PANQFMQYVA PNSYAAPPVN AYAQAPQQSW GAGPSCSASC APAQPSCTPC AAGGGGAGSY
FCFTADTLVE TISGEKKRMD ELEINDFVLT VRGNNVGYSP VNYWLHRVPS QKAEFIKFDL
ADGKSLKITA KHFIYKGKCT GNMGAAKVNQ EPVLAGEVEV GDCLYTRDGN YLMEQEVINK
QFVTEVGIYA PMTSNARIIV NDVLASCNNV YESQSLTNTF FSNIELMRQT LASIFDYSLD
SSETDLPFGT HTIMQMAEIV LPKNIMTL
//
