ID A0A2A2JR08_9BILA Unreviewed; 948 AA.
AC A0A2A2JR08;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN ORFNames=WR25_22007 {ECO:0000313|EMBL:PAV64184.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV64184.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV64184.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV64184.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV64184.1}.
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DR EMBL; LIAE01010269; PAV64184.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2JR08; -.
DR STRING; 2018661.A0A2A2JR08; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06352; PBP1_NPR_GC-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR001170; ANPR/GUC.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF503; RECEPTOR-TYPE GUANYLATE CYCLASE GCY-9; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR PRINTS; PR00255; NATPEPTIDER.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..948
FT /note="guanylate cyclase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013194915"
FT TRANSMEM 465..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 520..795
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 867..948
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 520..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 948 AA; 106956 MW; 4A980850B97FCC9A CRC64;
MKKRKSIFLI YFILSILFYG CSSKKISTVG TAYAGSGGMV KIGHLLPNNP NIGHEPDVLK
LCAKDLKDRK ILPINYTLQI LTMESCNKFS GVENAAYLHY KRNATVYFGP GCNSEILVIG
RLAPRWNVPI IAHMSGDDVL SDRSEFPTLG SVALTSASEM AKATLTFLQV NNWDQVGFVR
PSVNSERLSL HSLQHLLKKK NIELNTIIEL DPFVSVDEII SSGELTTLKS KARIIIVELG
MDLSAATNFM VAVHRQKMKG EEFVYIIPWL AHVNDYYPWE ATTVDKQEVK AAFEHTIIIT
AHGYDRKFFD EFQQKFSQAT GMLSSHYATL TYMSLYDALF LYGLALRDAY EEVGGYDVHQ
NGSLLWSKMT NRRFIGATGQ VLMNNKAIRV PSYATYYTTN GTLKIIVELE AKNSDRLRCE
KNPDQCSEHV AHEMIQFYWI SSTGKLPLAI PDCGFTGSDC DYTSYLIALG CIVFIVAIVP
ISYFIYLKQK ERLLYDMTWR IPRDNVRLVD ASKAKSEHSL MSKSTVSSSL SGSQTSKEKN
GIINAKQATS NGVRLAIKKY QQMRNITFPK SELKLLNELK LIESENLNKF YGIAFNQQNE
FIVMWVLCSR GNLEDILFND ELKLGRNFQV SFAKDVVKLT NFGTEQIISE KTYHNEIRLI
ASTEGGDPDQ EEIDTKIINR KYLQQAPEII RELVTRKILP KGTQPADIYA LGMVLYQILF
RVEPFHERGK SIAKLIELIA MSNDDDQIIR PSFPSSSREE GYSLQLLSCI EACWLELPEV
RPPIKKVRAM VNANLKSTGK GSLVDQMMKM MEEYTANLEG MVRDRTAMLE EAQKQADRLL
NSMLPKSIAE DLKVGKPVLP QLYSCATVLF SDIRGFTRIS STSTPFQVVT FLNDLFSGFD
AIIARHDAYK VETIGDAYMI VSGVPTENGN NHVQHIADIA LKMRSVRK
//
