ID   A0A2A2JSF4_9BILA        Unreviewed;       824 AA.
AC   A0A2A2JSF4;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   ORFNames=WR25_01677 {ECO:0000313|EMBL:PAV64597.1};
OS   Diploscapter pachys.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX   NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV64597.1, ECO:0000313|Proteomes:UP000218231};
RN   [1] {ECO:0000313|EMBL:PAV64597.1, ECO:0000313|Proteomes:UP000218231}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PF1309 {ECO:0000313|EMBL:PAV64597.1};
RA   Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA   Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT   "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL   Curr. Biol. 0:0-0(2017).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAV64597.1}.
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DR   EMBL; LIAE01010252; PAV64597.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A2JSF4; -.
DR   Proteomes; UP000218231; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF51; ANOCTAMIN-8; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        225..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        270..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        353..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        388..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        438..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        626..649
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        679..700
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        712..731
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          214..748
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
FT   REGION          549..570
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   824 AA;  94810 MW;  F6699EAD0ABA8F09 CRC64;
     MIHDKIGSLI QNGIVEGERF ALSSDLWRYA TSTHCDLLIV MTPNEDEVEA KTAVSWLLQQ
     IKEAEPLLRL EVRFHRLTSS YGIYITAEYK CLLKGAELCH IKKNVKQKFG GGMREFMFEE
     AQCYEGVATK STFFSSTERA IIVKQILDLI RASSGCVLSL PSKKITFAEG SAIISQLMST
     KLIDNVLPIH NSEFLSHLQR TWVLSLGEQP IEQIKDYFGT EIAMYFAWLG HLTTALWFPS
     FLGLIMFFFG EMKFKNYSPD KEDENDDYQL FVDMSFVVFA LFNCIWATCY LEHWKRKQAE
     FSFKWGTFDV ETESLLQDPR PGFRGDYLAP NPVSGRIEPF YPPWKHAMIR FGLTYPATFL
     CIVAMFLTMF LIFEIQDAVD FYLSESSLFW WLCHLPMVSY ALIIVASDKL YRRLALFLND
     LENYRTTSEY EDYLITKIAL FQFVTAFGSL FYIAFILKDM KRLQETLATL LITRQITQNF
     METVVPFLME RLKLSSLTYR MTRSMSDQTL RRHVENARKK SSLPDTIQIE HDLTYLSNNS
     PDMGLRYRKA GGGGDDHLDH QDSVQSKSED DSIKCEWEIC SPSSPRLPLP EFKPSITTEL
     TQAELESLMP EYARPLDDFL EMFIQFGYVL LFSPAFPLAA LCALVNNLIE IRVDAFKLTN
     TLQRPFGRRV KSIGAWEKMM ELLGIVGVIS NCALIGQSGL VQRIWPDLGS GGQILIIVVL
     EHVIIGIKLI IDLAVDDIPQ SVRIETAKME NYRREAFKRE TRLMGRVNSL YRVDSDDSME
     LCTEKRSSTR NSQRSKHRSI TPMLRTPSYR LATNMNTSYT HKLN
//