ID A0A2A2JT75_9BILA Unreviewed; 925 AA.
AC A0A2A2JT75;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Amino acid permease/ SLC12A domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=WR25_07435 {ECO:0000313|EMBL:PAV64871.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV64871.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV64871.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV64871.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV64871.1}.
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DR EMBL; LIAE01010235; PAV64871.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2JT75; -.
DR STRING; 2018661.A0A2A2JT75; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF55; POTASSIUM_CHLORIDE COTRANSPORTER 3; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 63..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..517
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 653..752
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 846..923
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 774..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..812
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 925 AA; 103086 MW; BE374A32444B0625 CRC64;
MEEAPSTASR KFTATFGHLA LYKDDDEGSG AATLFSAYTT PGPKERASSA HKKARIRNLG
PEFGTAVGIL FYLANTVAAS MYIVGGVEVF LMYLWPDAAI GGSDALHSPD FFGPKYNNFR
LYGTFFLIVQ VIIVAMGVKF VQLMAPVSLM CVILALLACF AGGIEKGIAQ TGQILTRAFC
DTKEFCSDYT KITMKCNMGF PGFNMDTLKE NWGAGYMNEH DVLPGERGKE GVEVIQDETS
TFAALLAIYF PAVTGIFTGT NMSGDLKDPQ RSIPTGTIAA TVTTSIIYFA LALLFGASVD
RAVLRDKFGR SIDNTMVAAM LAWPTPWIVT VGAVLSTFGA ALQCLCSAPR LLQSIAKDDV
IPMLAPFARV TKNNEPFLGL MITSVIAECA ILMGAVDKIA EVLDFFFLMC YAFVNVICFM
HSILKSPNWR PRFRYYHWTL SLLGAFLCFF IMFYSNWKYA LLAIGLTAFI YKYVEWKGAK
KEWGDGMRGL ALTTAQYSLM KVEDKDPHPK NWRPQLLICL KARWSKDLID KRTMSMLNLA
AQLKAGRGLS IACAFVKGSM DSETDRSRAK LIKDQIVRDM QIAKLKGFSK TMFWTNSQAT
GCISGLYQSI GIGGLKPNTI LINWPRLDDA DEVHLFCEEV INGAINENCV LVCKGITDFP
ETADRLTGYI DIWWIIQDGG ILMLIAYLLR KNKIWKGCTL RIFAIGESDR GVEMKRDLQK
YIYMLRIDAE VFIVDLLDQE ISEEVIEKTT QLEQRQKAMR DEFKRTRSGA YFNDGYRDDV
DSPPEQIGHR NSSRSLNVQS NDDSTRSSFV VSPPTISVNE DQETSFTTNS FEQFYNNPTL
NIELGGDDST LRINIHKMNT AVHLNKVILE NSPDSQLVLL NLPSPPRSRS AFLQSYMIYL
DVLSENLKRV LFVGGSGKEV ITIES
//
