ID A0A2A2JTM3_9BILA Unreviewed; 992 AA.
AC A0A2A2JTM3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=WR25_18638 {ECO:0000313|EMBL:PAV65023.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV65023.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV65023.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV65023.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV65023.1}.
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DR EMBL; LIAE01010229; PAV65023.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2JTM3; -.
DR STRING; 2018661.A0A2A2JTM3; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231}.
FT DOMAIN 539..877
FT /note="DNA mismatch repair protein MutS core"
FT /evidence="ECO:0000259|SMART:SM00533"
FT DOMAIN 899..992
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|SMART:SM00534"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 992 AA; 111585 MW; B68792C86B773793 CRC64;
MDDVDEDATI TAKTTNIGSQ AKRRRVVLSS DDEDENELMK MEVEEVTPST PKQGRKNIAL
STPVSSSKKR PGSSLSNSNS VATEFATSFI NSFRADENAE TTASAAVGTP SKSLKDWEKT
LNSTCFEIDR FRHEDFEFLK PDKIRDASKR RPDDPEYDAT TLLVPDKFIN DQTPAHQQWW
KIKSQNFDVL LFFKVGKFYE LFHMDAVIAV NCLGLAYMRG DLAHAGFPEH AYPKFADQLI
ARGYKVARIE QTETPQMLEE RNKKKKAGSK DKVVLRELCR ITSTATRTFG PLDASDDGEA
ATQHLIAIKE KELNDRPCYG VCYIDTSVGK FTVGQFEDDE YRSALRTLLA TSDIAQILLE
RGNISQQTKS ILTGMCCSVP IDHLVPKKQF FVAEDTVKVL QSLDYLGVDV PSWPETIRSM
LRTDHVLPEP AVEFDLAWSS LGAIIGHLQR CQIDVDMVTM KDFEMFRPFN DDDKKENVVS
LVKFDNLEML QDNAMVWEKV NESVTKMKGN WWEGRRVVLD GMTLYNLNIV PSDRSDPIDA
AASLYCTVNR CSTPFGKRLI RQWLCAPPCD KTEIGLRQDA IEWLLQPEND AFVESTTEIL
RKIPDLERLL QKIHTLGLKY RAEKHPDSRA ILFDTRKINS RKIKDLIMAI DSLKACSDVV
RLYGKLEEGC TLMDKCLKGT DISELKEDIS NFMKSFDRKQ AQEDGFITPV KGSDELYDEA
VLKEKAAHNV LDDYRKSVEK QLKCSVKFAG TGKNRLQLEI PTDMKLTNEF ELKSRAKKMS
KYTTPRLLKL IAELEVAEAE IVKQTNDATR RTFEAFDNKR SIWKTACDGI AIFDVLLSLA
KYAKTSGLEM CRPRFDFNAE KPFISICEGV HPCLANRPLP NANAVAFIPN DTQLGGEAAP
ILLLTGPNAG GKSTLMRQVA TLCVLAHTGS LVPAQSMHLS PVDRIFTRIG ASDKIMCGQS
TFFVELNETK LILKNATANS LVLFDELGRG TR
//
