ID   A0A2A2JZU0_9BILA        Unreviewed;       754 AA.
AC   A0A2A2JZU0;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
GN   ORFNames=WR25_05163 {ECO:0000313|EMBL:PAV67150.1};
OS   Diploscapter pachys.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX   NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV67150.1, ECO:0000313|Proteomes:UP000218231};
RN   [1] {ECO:0000313|EMBL:PAV67150.1, ECO:0000313|Proteomes:UP000218231}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PF1309 {ECO:0000313|EMBL:PAV67150.1};
RA   Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA   Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT   "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL   Curr. Biol. 0:0-0(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAV67150.1}.
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DR   EMBL; LIAE01009985; PAV67150.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A2JZU0; -.
DR   STRING; 2018661.A0A2A2JZU0; -.
DR   Proteomes; UP000218231; Unassembled WGS sequence.
DR   CDD; cd11959; SH3_Cortactin; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035716; Cortactin_SH3.
DR   InterPro; IPR003134; Hs1_Cortactin.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR10829; CORTACTIN AND DREBRIN; 1.
DR   PANTHER; PTHR10829:SF23; CORTACTIN, ISOFORM A; 1.
DR   Pfam; PF02218; HS1_rep; 4.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00499; P67PHOX.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS51090; CORTACTIN; 4.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          697..754
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          105..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          181..455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          515..550
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          593..636
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          648..696
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..156
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..226
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..306
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        358..434
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        435..449
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   754 AA;  83429 MW;  97B01982C8D1AB29 CRC64;
     MSMWRASVGV KPPIAKKPVD DDEWETDPDF VNDISEKESR WGAKTVVGSG HQAHISLSEL
     RNEALKADQV HQEKKLNEMP RASEGYGGQF GVQKDRVDKC AAGWDEKSEL SKHQSQKDYS
     VGFGGQYGVQ KDRQDKSAAG WDEKTELSKH DSQVDYKKGW GGQFGIQADR KDKSAVGWDE
     KAELAKHESQ TDYKKGWGGQ YGIQSDRQDK SAVGFEYHEG LHQHESQKLN KGVNPSDDQS
     RGEAEASKPF VRKSPPEVAS KGNASSLKAR FEQGAGDAES KIAAERERRA REDAEQRERE
     MKAKNTAAFE PPEPLAKHPS QMANRAVVNR VDDQTRDVEP ILKPSIGTKA PQIATEKGHA
     SDLKKRFEQM AVADEGQNRV MAERERRKRE DEELKEQQRK AEEERQRKME AEWNENEANR
     QQTDPDEEAR RHEQQWQAQQ NNPVHNQTRR SGPVAGAVAI MPGVVSQPKA TSPVAAPTIQ
     SLPQYEEPPT DIPPPAPVAV LPSAPTTVPA VLACSLRRKP SSDDEVDNDA EWEEEEKETK
     PAVSAFKTAI SPVKVEPSAP ALEKAAPVQD QYDVVPGEEP PIYDVVQSVK PAPMPAKSAP
     LPPATQKPWS QAHNQGAKGL DFPIPKEPKT KAPDTSRDLY DVVPFEDEIS VPEPSSAPKI
     NKAKTMSTKS QPGDLYELPP VEEPTSAASD PLSGSGSTGL TAVAIYDYQK QDNDEISFEP
     NDIITNIEQI DAGWWRGTCN GQHGLFPANY VELR
//