ID A0A2A2K069_9BILA Unreviewed; 1648 AA.
AC A0A2A2K069;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=PI3K/PI4K catalytic domain-containing protein {ECO:0000259|PROSITE:PS50290};
GN ORFNames=WR25_25021 {ECO:0000313|EMBL:PAV67189.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV67189.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV67189.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV67189.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV67189.1}.
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DR EMBL; LIAE01009984; PAV67189.1; -; Genomic_DNA.
DR EMBL; LIAE01009984; PAV67190.1; -; Genomic_DNA.
DR EMBL; LIAE01009984; PAV67196.1; -; Genomic_DNA.
DR EMBL; LIAE01009984; PAV67200.1; -; Genomic_DNA.
DR EMBL; LIAE01009984; PAV67203.1; -; Genomic_DNA.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR031559; SMG1.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF71; SERINE_THREONINE-PROTEIN KINASE SMG1; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF15785; SMG1; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1113..1481
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 28..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1648 AA; 187376 MW; 92032698B7CCED58 CRC64;
MKTPIGKPME TFNQISTELQ NVARRFLSYG TGKGKENREK EHLKKKRDKE SKTEEEAENV
LGEPRKLSPS EDWLRVRMLL DFFEHLERLI FYVTENGTCL PLCNPVRNFF VTNMSSCQEW
LSRAYVPAMV VAYFNGSFAQ VIRFGWSAFA DVEKKLQRAL QVQEKKRAKD KENEAEAGNN
HEEANEKEKE KEAEQTATTP NGTTKNDKDK KIPNQVQVIA LWMGRAMVEL ENEQAIIGLM
EWCKRIYNLS EVPKFLEALQ SMAAGRYELA LLMLNSAYTE ADLGDSIKSV IRDMILDCCT
HLRLPELLQS DISPMELFAW RHLVNVEGEP CHESDADAIN RVRQLTVFGK NERTLTGAKR
VTSDLVSCST RELHRWESIL TLTLRRTDVL QMQEDMNDLA RMVIIADGGN RTHGRLALVN
LISNNVLKKM QKKTNGELAN TESILTELDP LFVVSKESNR DRDIVERMRF SRAMILWAER
LVPDHLVMRP DIIIESAKLA RKTGNIILAK NYLKQASNSI IALQQKQLDQ QEFHPACVQL
QILTQNAKML WETSPSERPM NVVSAFNTLA ATYNIAQQLK HMVDVEMNNA SLDMGKSVVV
KKLNEHVCGT NLQLAKTCIR LAEWTEQLPS LQMPREFAVT RFWGDLQACS NDIGGNLPGS
LLYLATQMCP ELAKGQLQFG EWCLRAAAEL YSEQKKAEFV QQYRVLITDL TAMDALWECL
KNSTSLEQLS HEVANNVKYD SAVTNLLVSQ DSALVTKWVG NRSMLRLYYM QAVTAFYRYL
AQSDMIIKGN INTLSTTLRI LELLVKESEM LSQSIVENMH TTNVHLWKDI LPQLLARLSH
PSTKVRAPIM LLLSRICQAA PHAIVYQIVS GASSAYAMDA QPNAAAVLTP EDGAGPENKL
AAAQTQRNLM TSSCCELETY LTMSYPKLVK DVEDFITQLQ RVSLLNEEKW AFVLANLDHE
MDRRLEQIRV ETAKTRSFEF MDEEMREEII RHKQRLFTQQ VYTVINDLYA KTFEKSSPLT
NNESSFLEEC GHLLTNAIEA SRSAAASGGG PEKAWIPFKQ VLIKLQQRIS RRGAYTLQIN
DISEYLSKLH KTTIPMPGQE MLDFSEIVTI SQITKNAFVL PTKTRPKKLL ILGSDGSEQT
FLFKSREDLH LDERIMQLLE ISNQILSSGK MKREYPAYFA RHYSVTPFGG RCGLIQWVKG
ATPLFHIYRK WQSRQASLKT DSKQTRQGAQ ETERPTDMYQ KRLRAAFIEN NVENEILVDR
SKWPVQILKD VLKQLVDDTP NNLISRELWI RSGTCDTWWT VTQRFARSCA VMSMIGAILG
IGDRHLDNLL VNLATGELVH IDYNICFDKA CNFQMNFFLK SKNKLKYCFQ GKNLRVPETV
PFRLTQNIVH ALGPTQIEGT YRNSCSRVLQ ALRARSQVLS TILDAFVYDP LVDWTNLPTS
GSSAEAFTAL FSSGIGIAIN LAVYGTMDIH QQLPFDIAKE MLNVKIRELG QPWMANCSDL
SCALEDVLVA LKLQPPNQED RVKAGQRLKS ALSKHHQMMK EFRPMLRILA VKDDHVVNYL
SCYRRLFSEP IIRGHQQLEL VQESNLPLAK CPPEFTAAAE SLKGLCQCLL LLDKPTSSIP
PELQPTLLPL ITSSEQGVKS FGIFIWKE
//