ID A0A2A2K1N6_9BILA Unreviewed; 1793 AA.
AC A0A2A2K1N6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:PAV67800.1};
GN ORFNames=WR25_02670 {ECO:0000313|EMBL:PAV67800.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV67800.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV67800.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV67800.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV67800.1}.
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DR EMBL; LIAE01009882; PAV67800.1; -; Genomic_DNA.
DR STRING; 2018661.A0A2A2K1N6; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0052761; F:exo-1,4-beta-D-glucosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd04501; SGNH_hydrolase_like_4; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019826; Carboxylesterase_B_AS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR043534; EBDG/EBM.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR041351; Ig_GlcNase.
DR InterPro; IPR013830; SGNH_hydro.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR PANTHER; PTHR43536; MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE; 1.
DR PANTHER; PTHR43536:SF1; MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE; 1.
DR Pfam; PF00135; COesterase; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF18368; Ig_GlcNase; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF13472; Lipase_GDSL_2; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF52266; SGNH hydrolase; 1.
DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Serine esterase {ECO:0000256|ARBA:ARBA00022487};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1793
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012878111"
FT DOMAIN 325..390
FT /note="Glycosyl hydrolases family 2 sugar binding"
FT /evidence="ECO:0000259|Pfam:PF02837"
FT DOMAIN 453..566
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 662..778
FT /note="Glycoside hydrolase family 2 catalytic"
FT /evidence="ECO:0000259|Pfam:PF02836"
FT DOMAIN 1026..1107
FT /note="Exo-beta-D-glucosaminidase Ig-fold"
FT /evidence="ECO:0000259|Pfam:PF18368"
FT DOMAIN 1140..1542
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
FT DOMAIN 1617..1779
FT /note="SGNH hydrolase-type esterase"
FT /evidence="ECO:0000259|Pfam:PF13472"
SQ SEQUENCE 1793 AA; 193268 MW; C9870851F0629FE3 CRC64;
MGAALLSGVA GLAGVAAAQE SAGPVSLPAG PFNVTLLAGG IGVERDLAGA ETLVAAHAPY
TLSAWVRPAA RQAGEVALVA LGDPAGSARV LVLQNGRPAL RDGTARLTSG AELPTGQWSH
VAVSSDGRTA TLFVDGRRVG GGQAAAAAVR ARLSVGPVLP EQAHFGGDLV DVRAEADALS
ARDLSARARA RPDFALVQMW QVGVGWPFQK QANIGLTRQQ DAWTLPQARG DAYSRPVAKP
VPNSPVLAPV GPDRWQVNGW QLASATEVRA DGATLSGSGS DDGSPWRAAT VPGTVLTTLV
DRGVYPDPYY GLNNLRIPES LSRQDWWYRT RFTVPAAAQG KRLTLVFGGI NYAAEIWLNG
RRLGETKGAF IRGRFDITPQ AGGNTLVVRV SPPPHPGIPH EQSVKAGVGE NGGQLAIDGP
TFVATEGWDW IPGIRDRNTG IWRPVELEAH GDVRIGDPQV VSDLPLPRTD RADIYLTVPV
TNDSDAARTV TVRAGFDDVR VERTLTVAPG KTEVRFTPAE YRQLAVTNPK LWWPNGYGDP
ALHELSVELL DGQAVSDRKQ TRFGIREVSY DLSLFDHAGA LRRVNVQPTN GALAGTRLID
VRHEAIKQSP KGWVESLTLA GETSPAVTPV AEVLPEPHLT IRVNGVKIAA RGGNWGMDDA
LKRVSRDRLA PYFRLEREAH MNIVRNWMGN NNEDEFFDLA DENGMMVLND FWQSTQNFQI
EPEDPTLFLA NARDTISRYR NHPSIILWFG RNEGVPYPTL NEGLDKAVFE LDGTRWFTGS
SNTVNLQGSG PYNYRPIEGY FTDLATGFSV ETGTPSLSTL ESVKSYVPAA DRWPLGDVLA
YHDWHFSGNG DTKTFMAALD TMFGPATSFE DFERKAQMMN LETHKAMYEG FLGHLWTKNS
GRLLWMTHPS WPSNAWQIYS SDYDTHAAYY GAKKAAEPLH VQLNLPGNEL VVLNTTQQDR
PGLRVVTRVL GLDGRELWTR TDSVDALANR ATPLSAVPLE QVFATSPAVL VQLSLTEATG
VPVSSNFYWR GRTPADYRAL TTMAPATVDL KAAAPVSDAA ERRMEVTLRN TGSVPALAIK
LTLVDDKGER ILPAYYDDNY LSLLPGARPA RHPARLEPGR AMIGALLLAL AAAVATPAAP
PRVTVPGGQV EGERTVDRLL FRGIPYAAPP VGQLRWRAPA RVQKWQGVRG ATREASACLQ
NDYGWNHHDH VIGSEDCLAV DVGTSSLDGR RPVLVWIHGG SNRAGSPGEM IRSALVARGI
VVVGIRYRLG IFGFLSHRGF GGTSGNYGLM DQMAALRWVK DNITRFGGDP ARITIMGESA
GAQDVGLLQA APAARGLFAQ AIMGSGTPGF GIAWRPLAEA QRIGDQLDGL LGGVDPRRAS
ANALLAADLK LHDAWLTSDD YMWLRTTIDG SVLPASPAQL LRTARPVPLL IGTNVFELDL
PGGRGWRDAF LARSYGAAEP QARAYYGIEG GNDPAADPRA GTVDQRIATD ATFACPAQRF
AAIAAARGAP VWQYVFDGAP DGGMTAHGRE LSFIFGNARL GTADLQGLWS RFIPDGYPMI
DRRLLLAALA GAPLVPTAAL ADDAADRRLR EDWAWIGRYA DENARLIASR EPVGIVFMGD
SITQGWRDKK PGFFRPGRVG RGIGGQTTPQ MLVRFMPDVV ALRPRAVHIM AGTNDIAANT
GPMTLAQSEA NLTAMAQLAK ANGIRVLLAS VPPAANFPWR PGLDTVRPIR AINAWARDWA
TRNGATYVDY TPVLADAAGG MKPGLAYDGV HPTEAGYDAM AGVIEPILRK LRL
//
