ID A0A2A2K863_9BILA Unreviewed; 1261 AA.
AC A0A2A2K863;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 22-FEB-2023, entry version 19.
DE RecName: Full=Histone deacetylase interacting domain-containing protein {ECO:0000259|SMART:SM00761};
GN ORFNames=WR25_21646 {ECO:0000313|EMBL:PAV70063.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV70063.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV70063.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV70063.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00810}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV70063.1}.
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DR EMBL; LIAE01009359; PAV70063.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2K863; -.
DR STRING; 2018661.A0A2A2K863; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 1.20.1160.11; Paired amphipathic helix; 3.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR013194; HDAC_interact_dom.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR003822; PAH.
DR InterPro; IPR036600; PAH_sf.
DR InterPro; IPR039774; Sin3-like.
DR InterPro; IPR031693; Sin3_C.
DR PANTHER; PTHR12346:SF0; SIN3A, ISOFORM G; 1.
DR PANTHER; PTHR12346; SIN3B-RELATED; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF02671; PAH; 2.
DR Pfam; PF08295; Sin3_corepress; 1.
DR Pfam; PF16879; Sin3a_C; 1.
DR SMART; SM00761; HDAC_interact; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF47762; PAH2 domain; 2.
DR PROSITE; PS51477; PAH; 2.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00810}; Reference proteome {ECO:0000313|Proteomes:UP000218231}.
FT DOMAIN 661..763
FT /note="Histone deacetylase interacting"
FT /evidence="ECO:0000259|SMART:SM00761"
FT REGION 356..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..525
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..558
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1100..1116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1261 AA; 145292 MW; E46B2B0E38DF4DC4 CRC64;
MTYMVKDMKV EIVVIDTIEL CGNTRDVENG EFFDMMWASK TDPEGPKDPI KAQQQMAWIE
KILQNSDADY LIVAGHYPIH SMSSHGPTSC LQKELDLLLP KYNVSIYFSG HDHSLQHFQY
ESPSKHTVNY VVSGAASRAD SSKKNIHFYQ KAGHLKFHYP SSSAFSVFQF GQLGFSDGGF
IYATFHKTLA KLDFYDKEGR NLHLAKIKPR YLKCSKLVYW VNFRKMYHNQ SYDQYELNQQ
NNRVRVEDAL SYLDQVKTQF HDEPSVYTQF LDIMKDFKSQ QIDTPGVITR VSRLFKGRPS
LIIGFNTFLP PGFEVRVNGS RIIITEPSGN IQELDNDRDQ APVLHTPTAQ LAQIQSQQQP
IVEGTSSAVV EEAEQTDFDE QASEGRHQEE MDDEPSTEAG DNQFDLALDY VNKIKRRFAN
NPTVYKKFLD ILHGYQSAVI DPSQRGMADA YIMDAVAEIF ADDPDLLEEF KYFLPECQGL
NANSAMNRGE YANQLECFNY EDEGDEEEGM EEDSEDQEDE EEERETDQEG KKPEEGKKKR
KRRTAHGDEQ GPLFNAKRRW KKEQHFGEVI AKMSIKELSL YERMKTQLDP QELNVVLRLM
NLYSNGIATS NEFLKMLRPV LKGRKELMNE IRELLGENEE PEEKRPTAAE AEQAQQIDYA
TCRLLGVSYR KIADDAGSLP LCSGRTKLCN EVLNDTWASF PSWASEDSSS VSSKKTAYEE
FLYRTEDERF ELDILIEINK YAIEALEKVR RMVSTMSAVE QASFKLDDKL GASSGILMTK
ALKRVFGEQL PKYVEMLRKK PAACVDRVVD RLKEKENEWR DMQCYMNKSI DGQCEDVGPH
LILKYPEDRS ILDDASDLII HYIKRQANIQ KDEKRIVKRI MRKYVRDWFG VREEPMSDDE
EETPNEWTNH TVDLKPGTSG YRLIYGGNNL FLFFRLHQFI CERLGRIKAK HAVMIREYKP
PVRDPTSLYQ EVLNEIKNLL DSSIELSQFE DNIRMKFPVD GYVVFTMDKL IALIAKSLVS
LANDADCFET LKQYDKFRME KPPSVYDRSD RKNAIEAEYK QVSETKLNCK NCFLVYVINE
EKPIVTVELV DTETEIDDPP STNAVDKDKD SEMTEETSGE QLGESDEAVK DGKEDAKSDA
KKETGTKRPA TKCFLKRNVR LRKTKGFSQD DFATFDCKYQ IASGKAKMIG GTVEGLIKKR
KIDQSKRLEL QKAAFLRRHE RAKLLRREKG KCALLSENST ASRFKHPNFP WLSYLVYTRK
T
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