ID A0A2A2K981_9BILA Unreviewed; 907 AA.
AC A0A2A2K981;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=WR25_19397 {ECO:0000313|EMBL:PAV70504.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV70504.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV70504.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV70504.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV70504.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LIAE01009275; PAV70504.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2K981; -.
DR STRING; 2018661.A0A2A2K981; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231}.
FT DOMAIN 525..648
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 670..903
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 98..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 907 AA; 103952 MW; E1BA958566574FF2 CRC64;
MPHANEVDVA LTYLIQITAK RLPPHHILLS TQSLLDAISS RSDATVPELQ NNLIRLLKSV
DEKSLKDQFN EADYNEITTV AKQLENYIKY SLPSAAAANR ASTSSIKSEP RSSRTSSTTT
NNGTSKTSST RSRASNSEST ESSTNGQTTK EEEENLDNVL RQLNLRQVPK FQPVFEFANS
ESDDDGITTD ERKEERAEKH GQKLCEEEVE TLPDGTTRRI MKTKTISTTQ TVRHVTRSTK
GGGCPEITRK FVDGDRTLNE DEELKTDDFF KKSPLFERFN LHSKFPALTC SEEPIKQNGH
DEKEKETGQS QKTKSVERTS EVTQSVSQKK ERNGKLLGEM AATKLDSSEL KAKQIDSYLG
KLLLDRKGEG SYEENTVIKQ GKPEIEPVPA SPPRKHVVEY IQHFGNKENT AVDYLRGTTI
ASYISLNDNL RFQEEQFRKK LQFEFSTTGT SSVFPDFYNL SSLLDTDEFV KLTLPTKWAE
EIPDAKPIKE IDWLKKEAIG EEEDLICSFD VNDYLLMRAD TDQSKPLQIR GGPKDALIVY
GTQPVASLVF QEAFLVTYRT FVSSLDLINK LIKRYLYMVL SDDSVSSSAA KNTFSVIVRV
VDELTTFELQ SPLINSVTSF VYRLIRDGNF TFARILRKRL LERIEDPRPS PLSCIPKIIP
NKKQNLFDFS SSAIACQMTY LDAELFHAIE PPELLWWAQD QDEKKSPNLV KFTEHFNHIS
FWVRTLVLTP GSQSERERYL NKFLKIMKHL RKHNNFNSYL AIMSALLSSP VERLDWNRRL
WEQLTEHGSV MNTEKSHKNY RDMLQSAKPP VVPFIGVVLQ DLIFIHAGNP DKIPPERCCG
RTTLINFLKR WHQYAVLDSI RKLKKWNYDI QKDDPVFYFL HNSTKNFMND DQTWSRSYEI
KATQRRS
//
