ID A0A2A2KCX4_9BILA Unreviewed; 1313 AA.
AC A0A2A2KCX4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Sema domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=WR25_04399 {ECO:0000313|EMBL:PAV71750.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV71750.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV71750.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV71750.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV71750.1}.
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DR EMBL; LIAE01008930; PAV71747.1; -; Genomic_DNA.
DR EMBL; LIAE01008930; PAV71749.1; -; Genomic_DNA.
DR EMBL; LIAE01008930; PAV71750.1; -; Genomic_DNA.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR041362; TIG2_plexin.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF69; PLEXIN A, ISOFORM A; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01833; TIG; 3.
DR Pfam; PF18020; TIG_2; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 2.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 645..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..59
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 232..280
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 281..376
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT DOMAIN 377..463
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT DOMAIN 547..637
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT REGION 1012..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 671..713
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1313 AA; 147841 MW; EA251F931113650A CRC64;
MATSSCDRNA RTCFECLSAR DPYCGWCMRS NICSEEESCE KVLPNTGSGW LDFQDTFCPV
IKSVVPDKIQ ITTADYLNVT VDNIEEGQNQ TRAAFLLCPS DLLNSSPLSA LLQTREGHSR
RKGPSKCPHL VAPQSHLYVA VGERRNLSVK IQNLDPAIME EFRCEFRIGE TKHEKPALRS
GEDTVVCGEM RFDQAGGDGL LPVAFDVVWM SSEAPKAHVI DNTQKVAVEV YKCERLASDC
GTCITLDSAF YDCGWCKSQN SCSRQGECSS QWLNGSHLCA NPKILDVTPK KGPFGGRTVL
RIKGINLGRR PTDVQRAVQV ANVPCEVVTE EYKPAKEIVC VTGKATGTEN KGPVVIRLKP
DNYSYAAVSG FDFVYVQPAV SRIQPSRGPR SGGTDVTLYG TDLDAGSEVS VRFGDVDCRV
IKRTASELTC RTASATTDGP LPLRINFDGS HTRFPISINF EFSSSPRVHT IRPKYVFAAG
GMQIDVQRRE IGPVCVVEND ALMKCESPRL PEGDRQPTHA NSPVKASYAF DLDGMVTESD
RIDIYTNPSV ESFPETRYYR AGDDSLTING KDLNVAATER DFSVKIGGID CPLTSVANRV
ITCIPPSVKP LLPSGTQPEV VVKIGNLNYQ VGILSYDSPG MAASLMLLIA VFIILMTCLF
VCLFCVYRRK SSTQERKLRH LKLQMDNIEM KVATECKQAF AELQTSLDEY TAELPIGTAP
APFLTYREYC ARVLFPNNPH NHPIFQSVQV FPERANAVET ALRELHKLLM NKTFMLTMVR
TMESNKYFVA KDRVYVGSLL MVVLQEKMGY CTELLKQLLR ELIEKTVEKK LQPKILFRRS
ESVAERMLTA WFTFLMYDHL LKEPGRCLYN LYYSIKQQIE KGPQDGLTME SKYSLSEEKL
LRATFDYATL DMFVETDIPG MGNALVKAKR KCIEVKYRAL PYSKRPGPSD MDLVWITGRN
GGRIILQDID ETSRVEQGGW RKINTLAHYN VHDRAIVALV EKQKPFYEPS FLSDHSSLQS
RTSPPMSRAW QSISNSPSKE MDANYKLYHL VKPTEHGPNE GQEKMVTEIY LTRLLMMKGT
MQGFINDLLC AIFSCHSPTS PFPAVIKYMF DFMDEQAALH GITDPEVSHA WKSNALPLRF
WVNLIKNPHF LFDISKPNTV EGCLSVVAQT LMDACSTHDH QLTKDSPSSK LLFAKDMQEY
RKWVDSYYSE IRRLDKIKEE EMASLLERES RQHKNEFEVF SALNELYKYI EQYKEPLMDA
LESNEHALAS RLNIRLQDML ALMSDGDQVT DYESSTLGMG YNSSSRLMAR ERI
//
