ID A0A2A2KJV7_9BILA Unreviewed; 1164 AA.
AC A0A2A2KJV7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN ORFNames=WR25_24824 {ECO:0000313|EMBL:PAV74284.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV74284.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV74284.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV74284.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|ARBA:ARBA00010107}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV74284.1}.
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DR EMBL; LIAE01008362; PAV74284.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2KJV7; -.
DR STRING; 2018661.A0A2A2KJV7; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR002717; HAT_MYST-type.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF210; HISTONE ACETYLTRANSFERASE KAT7; 1.
DR Pfam; PF01853; MOZ_SAS; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..246
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
FT REGION 258..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..1011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..492
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..661
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..738
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..962
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..1011
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 144
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ SEQUENCE 1164 AA; 126294 MW; A5035B85431BD7AE CRC64;
MYICEFCLKY MKSSDILKNH QKKCDCRFPP GNEIYRDKDL SVFEVDGNLE RIYCQNLCLL
AKLFIDHKTL YYDVEPFLFY VATKLEYDGF HFVGYFSKEK YSAQKFNLSC IVTLPCFQGQ
GYGRFLIDFS YLLSRQEKLP GTPERPLSDL GRVAYSSYWK SALFEYFHEH LRKDGSVQVS
MTDIANATGI TFFDVCETLD ALGWFVKNER GITLDINWWM VEAHWKKMKA DKRRIWLSER
ALKWTPTVYT PSKDFAARSP LLSTPKRSPV ASGSTPTGVS LAAGLGPGSR GGRKGASVNL
KDKFEKDLPS TEDSTGSDND EAKPKQNKKS NCRDRFFPGR AGRRDDSPDE DDQDEDGPSG
GGKPQQKSSA KKRGRPPVST SGGGGGGSSG NYRRKAPAPR TANAGPGTGT GTSTTDRSAG
RKTAFEHPFG SSSEGSSEIS SDSDELDSTY NLGSYHGNAY GSGNGGGAGR KPQKGKPLPN
QQRKKRIPMK KPPGKSPGKV FPPNFGTRTR GKEQNSNSSK QQSSKSKEVQ ILKGNARCES
SSTIPAIDSS TEAGTSGLVS GAATTSGRCH DIEGEDDIVA SIPSGPVDRG PPPSSRVSRS
SSRLERPLSR ESSASGEGYF TDHHHSGACS DSSSQYDGSR GNTPRPIGDR VPDHEDAVNM
GGDPDEDGPN RCDQEDNEPP PNLQMETYAN VPVRERGKRQ PSAENSSSDE APPNLQAAFD
PNEILDENDP RFSRVDGNST DDEAPPQLSP VGIEGEIEPV YEDPEPPANV LDHRPSAPAK
LYPVEQEEQL QHQDEVVQQT GIQEQQQMPE VQQQQVQPSC GSMGPFSQVG SHSMECMPSS
VMHSTTPQQP YPGSLKQTTP GSVPSCQMQQ SQTPDQQIAF MSPQVQQQGA ICPNKQPNSV
SSVHSQHNNS HEMIAGPLSQ QGATFHSDPS TPLRSHHGAS FGSPPQPIQA STSRQSAEGP
ANVSGHRRSG GGTSVDPVVS QQAGNVSGSS RQKSSRSSHH HPSQQTQLEQ AQMVAQQQMV
QQINLQQQGA QFYGIYGNYA YPNPASFYPP PTAQFEQFYH QYAQGYPSSS HSMYNQGAII
PPHPSFYPSA GTPNGFQAGT SFGGSSGSRG QGGVNPAAAA AAMNLPRYPP GAAHNDVQAQ
MNAMLPYGMY YQPANASNQF FGKQ
//
