ID A0A2A2KJY0_9BILA Unreviewed; 1561 AA.
AC A0A2A2KJY0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN ORFNames=WR25_10899 {ECO:0000313|EMBL:PAV74346.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV74346.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV74346.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV74346.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV74346.1}.
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DR EMBL; LIAE01008347; PAV74346.1; -; Genomic_DNA.
DR STRING; 2018661.A0A2A2KJY0; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF1; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 86..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 470..488
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 500..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 674..696
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..805
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 825..846
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 855..873
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 919..938
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1029..1056
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1107..1125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1137..1158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1234..1257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1324..1348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1483..1517
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..737
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 320
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 649
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1002
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1561 AA; 177949 MW; 25522F6A2D81387B CRC64;
MMSSGEDEEP PTGIGGGDSQ GQGPTGSQAG GSIGGGVSGE HEQERTDLWQ QTLQAAVAAS
AGGDPNKKRP AQRKPLRQAN VVERPFEFLI LLMICLNCIA LAVTQPYPAQ DSDSINAKLE
RVENVFIVVF TIECILKVIA YGFMFHPSAY LRNAWNVLDF IIVVIGIIST VLAGMHLQGF
DVKALRAFRV LRPLRLVSGV PSLQVVLNAI LRAMIPLLHI ALLVLFVILI YAIIGLELFC
GKLKQTCIDP ATGQLAMKDP TPCGNDGTSF QCIPTDAMIA MGVSWECSNN TNWTGPNFGI
TNFDNFGLAM LTVFQCVSLE GWTEVMYWVN DAVGREWPWI YFVSLVILGS FFVLNLVLGV
LSGEFSKERE KARARGLFQK FREKQQLEED LKGYLDWITQ AEDIEPVNED EQDQEPQPQT
QQQQGEEQDE EGEERPDEAR PSKWSGRIKR LEKLNRRCRR SCRRLVKSQT FYWLVILLVF
LNTLVLTSEH YGQSDWLDEF QNWANLFFVI LFTMEMFLKM YSLGLTTYTT SQFNRFDCFV
VISSILEFIL VNCKLMKPLG VSVLRSARLL RIFKVTKYWT SLRNLVSSLL NSLRSIMSLL
LLLFLFIVIF ALLGMQVFGG KFNFNPQAPK PRANFDTFIQ ALLTILTGED WNTVMYNGIN
SFGGVGTVGV VVSIYYIVLF ICGNYILLNV FLAIAVDNLA DADSLTNAEK EEEQQDLEAE
DEYDENEEGA ELDEHEGDDD LVTARPRRMS ELPQTTNIKP IPKASSLFIL SHTNPFRVFC
NKVVNHSYFT NSVLVCILVS SAMLAAEDPL KADSPRNLIL NKFDYFFTTV FTIEITLKVV
FFGLILHKGS FCRNAFNLLD IIVVAVSIIS PILKSDAFSV VKILRVLRVL RPLRAINRAK
GLKHVVQCVI VAVKTIGNIM LVTFMLQFMF AIIGVQLFKG TFFYCNDISK MTEAECRGEY
IHYEDGDPTK PVAKKRAWQN NDFNFDHVGN AMISLFVVST FEGWPDLLYI AIDSNEENKG
PIHNNRQAVA LFFIAFIIVI AFFMMNIFVG FVIVTFQNEG EREYENCELD KNQRKCIEFA
LKAKPHRRYI PRNRFQYRVW WFVTSRAFEY LIFLIIVLNT VALACRHDPS SQSFNDILDK
LNLCFTSVFA FEAFFKIIAL NPKNYFGDRW NAFDFIIVLG SFIDITWSNL NPDNKSLISI
NFFRLFRVMR LVKLLSRGEG IRTLLWTFMK SFQALPYVAL LIVLLFFIYA VIGMQVFGKI
ALDDSTEIHR NNNFQTFFSA VLVLFRSATG EAWQQIMLSC SERDEVRCDR KSDDPGQKCG
TNFAYPYFIS FFMLCSFLVI NLFVAVIMDN FDYLTRDWSI LGPHHLEEFV RLWSEYDPDA
KGRIKHLDVV TLLRKISPPL GFGKLCPHRL ACKRLVSMNM PLNSDGTVCF NATLFALVRT
NLKIYTEGNI DEANEQLRSA IKRIWKRTPA KMLDEVVPPA GKEDDVTVGK FYATFLIQDY
FRRFKKRKEL EAKGIVPTHT PQAMALQVEH LHLFFISAKN FHVLVWNTRN TLFKNSMHQI
S
//
