ID A0A2A2KWK7_9BILA Unreviewed; 866 AA.
AC A0A2A2KWK7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Calponin-homology (CH) domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=WR25_24776 {ECO:0000313|EMBL:PAV78345.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV78345.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV78345.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV78345.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- SIMILARITY: Belongs to the alpha-actinin family.
CC {ECO:0000256|ARBA:ARBA00010255}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV78345.1}.
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DR EMBL; LIAE01007576; PAV78345.1; -; Genomic_DNA.
DR EMBL; LIAE01007576; PAV78346.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2KWK7; -.
DR STRING; 2018661.A0A2A2KWK7; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd21216; CH_ACTN_rpt2; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF442; ALPHA-ACTININ, SARCOMERIC-RELATED; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00435; Spectrin; 3.
DR SMART; SM00033; CH; 2.
DR SMART; SM00054; EFh; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00150; SPEC; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..70
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 79..183
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 724..758
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 764..799
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 201..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..222
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 866 AA; 99886 MW; 800D06CAB0CE8D1C CRC64;
MLLLEVISGE PLPRPDRGKM RFHKIANVNK ALEYIESKGV KLVSIGAEEI VDGNVKMTLG
LIWTIILRFA IQDINVEELS ARDGLLLWCQ RKTAPYNNVN VQNFHNSWKD GLAFCALIHR
HRPDLIDYAP LHKGDPIHNL NYAFDVAEKH LDIPRMLDAE DVARNPDEKS IMTYVSCFYH
AFRNMNDRQP PPVVIQPPPQ PRPQIQTPQP QPIPTRIVAP PPPPERDWRK DAETAANRIM
RVLKVNQENE KMMEDYENLA SDLLAWINRW MPWLANRAND MTLPGAQQKL DDYRNYRRRE
KPPRIEDKGR LETLFNTLQT RLRLSNRPAF MPKDGHLIKD INAAWGRLED SEKGFEDWLL
SEIMRLERLE HLAEKFRRKC ALHEEWANGK EEALMSNDWK SCGLYKIKAL RKRHEAFESD
LGAHQDRVEQ IAAIARELNN LRYPDIGPVN ARCQTICSQW DRLGQLSSQR RATLEEAERV
AERLDALYLD FAKRAAPFNN WLDGAREDLA DLVIVHSMGE IEELCSAHDA FKSTLGDADK
EFGSISAIEQ EIERLVETHG LDRELLRNPY TDLSAHEIRR KWAEVQGAVP RRDGQLQSEL
KRQQNNERLR TIFAERANQV GPWLEKELEQ VLAIGLGGRG RLEDAIHQLR GIHQNALSYK
PNLDELERIH QEMQENFVFE NRKSKYSMES LRVGWESLIT SINKTINELE NQILMRDSKG
ISEDQISEFR ASFNHFDKDR LGLDAEQLRA CLISVGYNIR PGREGDADLH RIMAHIDPNR
MGHVPFEAFL DFMTAEHADN DTVEQMIDSF KILASGKPFI TAEEIRRELP SEQAAYCMAR
MAPSNDPSAP HGAFDYVTFS RTLYGQ
//
