ID A0A2A2KX65_9BILA Unreviewed; 750 AA.
AC A0A2A2KX65;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=WR25_09560 {ECO:0000313|EMBL:PAV78518.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV78518.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV78518.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV78518.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV78518.1}.
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DR EMBL; LIAE01007551; PAV78518.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2KX65; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00057; FA58C; 1.
DR Gene3D; 2.60.120.1190; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR048525; DDR1-2_DS-like.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR24543; MULTICOPPER OXIDASE-RELATED; 1.
DR PANTHER; PTHR24543:SF335; SMOKE ALARM, ISOFORM D; 1.
DR Pfam; PF21114; DDR1-2_DS-like; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00231; FA58C; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..750
FT /note="Protein kinase domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012674643"
FT TRANSMEM 394..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..187
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 582..750
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 475..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 750 AA; 83100 MW; 31E30A566F0BBC51 CRC64;
MRVLNRRTLL DLFSIFLIIS SSDGLRLEEC NSQPLGMASG AIEDSQITAS SSFDKQSVGP
QNARLHTELA SGAWCPKPQI HSSSYEYLQI SLNGTHLITG VETQGRYGNG TGKEFPSEYM
IEYQRPGTDL WIRYRNRTGQ NHMTGNFDTT TAVMCHLDPP IVASKIRIVP HSKQTRTVCL
RAELHGCNYK DGLLWYTTVP EGSRIGDQDF RDHIFEDTGM YAETGTKRGL GILSDGFVAV
ASPFEENAIN GAWIGWNKHH TGGAVNLLFE FDQIRNFSEV TLAAYGHRMD SIDVIFSQDG
NTFPLSSQIS SLDKDRLLSN SSAKRYDLRI PLHKRMAKKV RITLKFSSDW LFLTEVHFSS
GPISVSDLEE LALYNDVTSY NIGDISEDGH GKNAIAILGL TVLFVILSAI LCSILCLRRN
RPKSHKAGIY DQPIKRDLII THVGNKPTCN IFPTHSYLGQ SAVFGAGNLY SSDKTTSTSV
SSKSSSSNKH SPPNWSDFHF PPPPHTSGEE RIYAEPCMTL PLLPSQKQNI STPKSAKHTS
TTVRQPAKTK NANEDSVHYA AANIFSDSYG FDKIPKFSFA NLQIGGDLGE GKFTVIRDCI
MPNGYRAAYK SVKDKNNMHA RKALLDELKT LHACGDNHPH ILKLYGADET ASLVLEYCAL
GDVRHFLKTQ MQPITPSILL RICADVCSGM VHLENLGLVH GHLMPSNILL TDQLRAKVAS
PRGPAHHAQL RYSAPESILA VKMKFQFVQI
//
