ID   A0A2A2KXI1_9BILA        Unreviewed;       888 AA.
AC   A0A2A2KXI1;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 10.
DE   RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN   ORFNames=WR25_21132 {ECO:0000313|EMBL:PAV78701.1};
OS   Diploscapter pachys.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX   NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV78701.1, ECO:0000313|Proteomes:UP000218231};
RN   [1] {ECO:0000313|EMBL:PAV78701.1, ECO:0000313|Proteomes:UP000218231}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PF1309 {ECO:0000313|EMBL:PAV78701.1};
RA   Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA   Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT   "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL   Curr. Biol. 0:0-0(2017).
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAV78701.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LIAE01007535; PAV78701.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A2KXI1; -.
DR   STRING; 2018661.A0A2A2KXI1; -.
DR   Proteomes; UP000218231; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   PANTHER; PTHR10796:SF185; SSD DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        283..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        314..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        383..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        410..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        507..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        719..737
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        744..765
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        771..792
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        813..839
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        845..868
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          280..438
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   888 AA;  101361 MW;  07A0E71A7AC02AA2 CRC64;
     MPAGNLDAPA RIRRELAETD FEMDKLRRDL EMLMTDARGE EYLPSAPLDY FSFIDNNQIG
     EYANETRFKR QDDFDGKTVR PKRKRKESKK TINKLVAAKR DILRFYVVHK NFENLLQSKY
     LGPLYEYTNE MMKITTEYNG KVIGIDDFCD RGTEKTCTNT LNSWIKHADV LFRDGTVKAN
     PNLQLSYPVL YLFNRPKDIG NVIYGVDVEG EKNEIKGARV LTLHWFVNYP ATPENNAAYL
     AYRERLNDFW QEIATKTELE FIPHNDKAMD DEMMKIIEST VPFAVPATIM LIIFVTISNF
     SFNKVKSKPV EMYLGVWCVI IALIMTFGIF FYCGASFNPV TSTMPFLVLA VGVDDDFLMV
     GAWRELDRRL PVHQRIALVM GDAGASITVT SVTNLFCFAL GWLMCSTPAV ADFCLITAFG
     VFLDYLTQIT FFAAILTYSG RKEETGGLAS CCYKKTDVGP AESSKNDANN TMNENKIDCQ
     HHAKAANIPY MHKFFEHRIA PFILKKWIKV ISWLLYAVYA VISLYGCCIL KVDISPVKYI
     RDNSPIQTFV KLADKYIWAD NVMPTFYVMK PPDLRDPTQR AQFNEMVFRL EHTNYSIGRI
     STNLWVWQYQ EYMNDFPSVD LSVEFYNKKH LRDFFAQLDY SQYRDKVKII DNATYNEPCV
     SAFSFQTSFY GLDSWDKRQA ELFHWRAIIN EYPQYDMFLA GIFSPFLIDQ RRTIAPSSMQ
     TIGSALLMMA VISIFFLPDV QSVFLMTFSL LSISMGVCGG LALLGSDLDS VSMGCIVMAI
     GLAVDYSVHI CYRYHRSEKK TGPDKVQDAL SSVGWPVTQA VGSTLCGLAV LPLVPAYLIR
     VFFQTVYLVN IIGLIHAVLW LPQLIAALDP CDRVPLRFQN SKIKLSIA
//