ID A0A2A2L1N2_9BILA Unreviewed; 525 AA.
AC A0A2A2L1N2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=EGF-like domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=WR25_25893 {ECO:0000313|EMBL:PAV80072.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV80072.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV80072.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV80072.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV80072.1}.
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DR EMBL; LIAE01007321; PAV80072.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2L1N2; -.
DR STRING; 2018661.A0A2A2L1N2; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 7.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270:SF66; CUB AND LDLA DOMAIN, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR Pfam; PF00057; Ldl_recept_a; 6.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 8.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 8.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..525
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013059170"
FT TRANSMEM 290..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DISULFID 51..66
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 72..84
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 79..97
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 91..106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 135..147
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 142..160
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 154..169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 213..228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 373..388
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 394..406
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 401..419
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 413..428
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 480..495
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 525 AA; 58607 MW; 1AF72FB09846B95C CRC64;
MSISFYAFLA SLVLVQSTPS VMPPVPSPCN TSLHLDCGRG RFRCIPLDWM CDNTPDCENG
MDELGCHYLH DCPIGSMICR NGDCVAKKFK CDGEWDCQKG EDEKFCSQII PGEKNDTSAE
GKVDTEDDYT LAQKCESPRF LCSSGQCLTQ DAVCDGYADC PEKEDELNCT RRKTTTGRTV
KDAEDDEEMD IVCKADTVAC ANKYTCIPSR WICDEEQDCE DGSDEANCKG EVTHHQQHAI
NCSADDGSFR CDAVNGIHKC IFKNLTCNGV NDCPSGEDEA YFCQHQYSNV WIYLTLFVLI
AISSVSIILL RKYFGFFKMS SQLIWLFCLI VISWISDQTS TLSASAYSIS CNSTIHFDCK
QGEFRCIPIS WACDNVPDCD NDEDELGCRY NFDCPLGTMI CSTGECIAGK FKCDEEIDCR
MSDDEMYCPR VVKTFIREEI STQPTNLMID EQPQDEELKC QPDEFECSDE KKCIPSGYVC
DGTWDCSSGY DEKNCLEPAD KASTGCFDAL ALLLNSVIVL AALVF
//
