ID   A0A2A2L220_9BILA        Unreviewed;      1073 AA.
AC   A0A2A2L220;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   13-SEP-2023, entry version 21.
DE   RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE            EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN   ORFNames=WR25_19932 {ECO:0000313|EMBL:PAV80143.1};
OS   Diploscapter pachys.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX   NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV80143.1, ECO:0000313|Proteomes:UP000218231};
RN   [1] {ECO:0000313|EMBL:PAV80143.1, ECO:0000313|Proteomes:UP000218231}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PF1309 {ECO:0000313|EMBL:PAV80143.1};
RA   Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA   Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT   "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL   Curr. Biol. 0:0-0(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC         EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAV80143.1}.
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DR   EMBL; LIAE01007310; PAV80143.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A2L220; -.
DR   STRING; 2018661.A0A2A2L220; -.
DR   Proteomes; UP000218231; Unassembled WGS sequence.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR   CDD; cd20335; BRcat_RBR; 1.
DR   Gene3D; 1.20.120.1750; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR031127; E3_UB_ligase_RBR.
DR   InterPro; IPR002867; IBR_dom.
DR   InterPro; IPR044066; TRIAD_supradom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR   Pfam; PF01485; IBR; 1.
DR   SUPFAM; SSF57850; RING/U-box; 2.
DR   PROSITE; PS51873; TRIAD; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          774..1013
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51873"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          37..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1073 AA;  123570 MW;  1E55D045ACD8C06B CRC64;
     MIHWRGEDDD ESESPENQPI VVRKDLIRLP PRPCRLNRQP HSRELYKGDD EGETDPSNVY
     RMHYSDCIPT RHRPSDVVDC EPSTSSSSEL LNEVINQTAL HAALQSEVVL NAQATELSLG
     PRLRLLLEDE LAQVRRKEEN DSNGIYYMLD YIKINTSSTS SDPLRRIRIS APDQINFTNE
     CQKAHQALVQ LDLEANVDGS VELAIPSGGY GFSLGDGGTC RLIWKDDTLH LRCPAVLREQ
     FSNEDSRNPT TRHLSGWELM CLKKGEEKEK EKFVHKEDLI LKFDDLNIRN EFLKSHPKIA
     KSSLKMLPGY NPAREEKVVM FWYIRWICEP IKYSSYSTVE ATVKLKSVLD VDYCWQVLEA
     NGFVVSNTTR NRRFNDPIET RKLFIECGIP NWFSTQGMLT DLISRILDIN SIEYEDIYFI
     RMRNCPENVV SMRRELAKIR KRIYMAALDM RYPLHERINS RNIDLTDMYY FESAPYPWPF
     EVLPGRVLFA DPDPWSRDAE KRMDATGFPI DRRDDASAEI IWTDQEKAEI FTNYFSRITP
     DGCNWHMRKH DRNGARLTFG YRTTLYISKA IRIACDSELR DLDKDLRNRH YQYPEDGPPV
     KDELVKRERY WAQLIDENDD LFKSNDSDNA TMLTVEGYPR ELFDDALHQR VVTDVNLMRK
     TLTIWGPADE VNRLIDNTRH FFNHPDEFFV ETEIAIAPPR FPGHIRPVLV KIGLEKISQI
     TGGAKISTNG TNPRNWTALK FKGSIAQFDR LDKFLNELLE ELPSFCGVLP DFSYVPHCPI
     CLTMITKAFY CLELCDHYYC LDCFANMVLD KVQSRDLSFV CLKPDCQHKI AVTDILRIIL
     GPSNRIKSLD AVKLEPLLRS LKDSIAFGDT ETMRVCPTPD CYGLIPFNPN DQPPGLPTSR
     QIKCVECNKY RCVGRNCLSR PHPGETCAQA EILRQNADES LKAYKRVVGE QNLKSCPSCT
     MLIEKDVGCN HMECTRCRMH FCWECGYQSK ERAELYRHLG EAHGSYGGGW QIQGNQVLQA
     PPGEFVPNDV MGVAVFMEEM NEIAPAIWAN WPGVNPNHID AELFEAMLED DFN
//