ID   A0A2A2L495_9BILA        Unreviewed;       844 AA.
AC   A0A2A2L495;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Degenerin mec-10 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=WR25_06901 {ECO:0000313|EMBL:PAV80897.1};
OS   Diploscapter pachys.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX   NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV80897.1, ECO:0000313|Proteomes:UP000218231};
RN   [1] {ECO:0000313|EMBL:PAV80897.1, ECO:0000313|Proteomes:UP000218231}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PF1309 {ECO:0000313|EMBL:PAV80897.1};
RA   Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA   Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT   "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL   Curr. Biol. 0:0-0(2017).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAV80897.1}.
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DR   EMBL; LIAE01007222; PAV80897.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A2L495; -.
DR   Proteomes; UP000218231; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR004726; Deg-1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00867; deg-1; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF276; DEGENERIN DEG-1; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        63..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          335..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          427..463
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        335..406
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        427..446
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   844 AA;  94704 MW;  C29A674C5C4B4460 CRC64;
     MKSDGDNNHC GTPSRKRSFV EGLEEIMPSP QDYKEKVVKF SDLTTAHGWK RAAIAKSEIS
     KSFWILLLIA LVGMFLFQAY TLTDKFRKHE TITGISLKFD KVDFPAITFC NLNPYKRSLI
     RLVPSIRDTM DVYDNAKFLG KGSKQDGAKL SRKEKAAKSI ANVEAQFADE IRKDKEERMK
     NAGGKLNRSN SLTRVKREIT SNQIVDPQLE AIEAHCVCFG SVDMECIRFE SPPETDTAKC
     ICTYNKFTEE AWPCYNRTIW YDHTCPSCNE DGHCDYNLDV VLENEVKHEW PCVCKNQTGK
     TLDREDKPYC IPKAGKGPTV IRKLWAINET FTTSTTTTTT TTTTTPPPTT TTTTEPSTST
     STTTTTTTTT TTEPPTTTST MTSTSTTTST TPVPSTNLST TPQPTTRRPR PTLPLWASNR
     QWIITTPKVP RTTRPRPTTT TTPRPTQPTT TVPPTARPDQ SEIVSNPETI KAMGFTGMTD
     GVAMLTKAKE NLMFTMAGLS ADQRRVLSHQ KHEFIEMCSF NGKQCDIDTD FREHIDPEFG
     NCFTFNYDTN NNFTSSRAGP MYGIRVLLFV NTSDYMSTSE SSGVRITIHG ATEYPFPDTF
     GYSAPVGFAS SFGMKKKVME RLPAPFSNCK AGADNNDHDM QTYIYQGFDY SPEGCHRSCF
     QNWLLEKCDC GDPRFPVPPG HKHCSAFNAT ARDCLDKNLG STGDFHHMTT RDMKCVCEQS
     CRETIHEVTF SASKWPSGAT DLGDCGGMTE EECENYYRLN AAMVEVFYEQ LNYELLQESE
     AYGFVNLVAD FGGHLGLWLG KNLMQIKMLL YLLKINKIDF IKKDRNKSCS SKLSKSELTR
     DGRS
//